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Xanthii fructus inhibits malignant behaviors of lung cancer cells
- Source :
- Infection International, Vol 6, Iss 2, Pp 41-47 (2018)
- Publication Year :
- 2018
- Publisher :
- Sciendo, 2018.
-
Abstract
- Objective This study aimed to investigate the influence of Xanthii fructus on the expression of small noncoding RNA (sncRNA) and the malignant behaviors of lung cancer cells. Method A549 cells were treated with Xanthii fructus extract. SncRNA expression was detected by real-time PCR. Proliferation, anchorage-independent growth, and invasion capacities were determined using Cell Counting Kit (CCK)-8, soft agar colony formation, and Matrigel assays, respectively. Results Xanthii fructus extract downregulated microRNA (miR)-21 expression and upregulated PIWI-interacting RNA (piRNA)55490 expression. The proliferation, anchorage-independent growth, and invasion capacities of A549 cells were strongly inhibited by the extract. Conclusion Xanthii fructus can inhibit the malignant behaviors of lung cancer cells.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
business.industry
Medical laboratory
medicine.disease
noncoding RNA
lcsh:Infectious and parasitic diseases
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
030220 oncology & carcinogenesis
Internal medicine
medicine
lcsh:RC109-216
business
Lung cancer
Xanthii fructus
lung carcinoma
Subjects
Details
- Language :
- English
- ISSN :
- 25440349
- Volume :
- 6
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Infection International
- Accession number :
- edsair.doi.dedup.....8a0b061fc2bb43ea2fa7e24380178f02