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Salmonella Interacts With Autophagy to Offense or Defense
- Source :
- Frontiers in Microbiology, Frontiers in Microbiology, Vol 11 (2020)
- Publication Year :
- 2020
- Publisher :
- Frontiers Media SA, 2020.
-
Abstract
- Autophagy is an important component of the innate immune system in mammals. Low levels of basic autophagy are sustained in normal cells, to help with the clearance of aging organelles and misfolded proteins, thus maintaining their structural and functional stability. However, when cells are faced with challenges, such as starvation or pathogenic infection, their level of autophagy increases significantly. Salmonella is a facultative intracellular pathogen, which imposes an economic burden on the poultry farming industry and human public health. Previous studies have shown that Salmonella can induce the autophagy of cells following invasion, which to a certain extent helps to protect the cells from bacterial colonization. This review summarizes the latest research in the field of Salmonella-induced autophagy, including: (i) the autophagy induction and escape mechanisms employed by Salmonella during the infection of host cells; (ii) the effect of autophagy on intracellular Salmonella; (iii) the important autophagy adaptors that recognize intracellular Salmonella in host cells; and (iv) the effect of autophagy-modulating drugs on Salmonella infection.
- Subjects :
- Microbiology (medical)
autophagy
Salmonella
lcsh:QR1-502
Salmonella infection
Review
Biology
medicine.disease_cause
Microbiology
lcsh:Microbiology
03 medical and health sciences
xenophagy
medicine
Xenophagy
Pathogen
030304 developmental biology
0303 health sciences
autophagy adaptor
Innate immune system
030306 microbiology
Intracellular parasite
Autophagy
medicine.disease
Cell biology
drug regulation
Intracellular
Subjects
Details
- ISSN :
- 1664302X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Microbiology
- Accession number :
- edsair.doi.dedup.....8a054304996e5a0938563609203c8044