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Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals
- Source :
- Lab on a Chip, 13(12), 2328-2336. Royal Society of Chemistry, Lab on a chip, 13 (2013): 2328–2336. doi:10.1039/c3lc00055a, info:cnr-pdr/source/autori:Arima V. [ 1 ] ; Pascali G. [ 2,3 ] ; Lade O. [ 4 ] ; Kretschmer H. R. [ 4 ] ; Bernsdorf I. [ 4 ] ; Hammond V. [ 5 ] ; Watts P. [ 5,6 ] ; De Leonardis F. [ 5 ] ; Tarn M.D. [ 5 ] ; Pamme N. [ 5 ] ; Cvetkovic B.Z. [ 7 ] ; Dittrich P. S. [ 7 ] ; Vasovic N. [ 8 ] ; Duane R. [ 8 ] ; Jaksic A. [ 8 ] ; Zacheo A. [ 1,9 ] ; Zizzari A. [ 1 ] ; Marra L. [ 1 ] ; Perrone E. [ 1 ] ; Salvadori P. A. [ 2 ] ; Rinaldi R. [ 1,9 ]/titolo:Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals/doi:10.1039%2Fc3lc00055a/rivista:Lab on a chip (Print)/anno:2013/pagina_da:2328/pagina_a:2336/intervallo_pagine:2328–2336/volume:13
- Publication Year :
- 2013
-
Abstract
- We have developed an integrated microfluidic platform for producing 2-[(18)F]-fluoro-2-deoxy-D-glucose ((18)F-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that were comparable to those reported for commercially available vessel-based synthesisers (40-80%). The system would allow researchers to obtain radiopharmaceuticals in a dose-on-demand setting within a few minutes. The flexible architecture of the platform, based on a modular design, can potentially be applied to the synthesis of other radiotracers that require a two-step synthetic approach, and may be adaptable to more complex synthetic routes by implementing additional modules. It can therefore be employed for standard synthesis protocols as well as for research and development of new radiopharmaceuticals.
- Subjects :
- Engineering
Biomedical Engineering
Bioengineering
Nanotechnology
02 engineering and technology
01 natural sciences
Biochemistry
Fluorodeoxyglucose F18
On demand
Pressure
Humans
Sodium Hydroxide
Process engineering
REACTOR
RADIOSYNTHESIS
MICROFLUIDICS
MICROREACTORS
business.industry
Continuous flow
010401 analytical chemistry
Temperature
Equipment Design
General Chemistry
Microfluidic Analytical Techniques
Modular design
021001 nanoscience & nanotechnology
0104 chemical sciences
Single bolus
Positron-Emission Tomography
Radiopharmaceuticals
0210 nano-technology
business
Subjects
Details
- Language :
- English
- ISSN :
- 14730197
- Database :
- OpenAIRE
- Journal :
- Lab on a Chip, 13(12), 2328-2336. Royal Society of Chemistry, Lab on a chip, 13 (2013): 2328–2336. doi:10.1039/c3lc00055a, info:cnr-pdr/source/autori:Arima V. [ 1 ] ; Pascali G. [ 2,3 ] ; Lade O. [ 4 ] ; Kretschmer H. R. [ 4 ] ; Bernsdorf I. [ 4 ] ; Hammond V. [ 5 ] ; Watts P. [ 5,6 ] ; De Leonardis F. [ 5 ] ; Tarn M.D. [ 5 ] ; Pamme N. [ 5 ] ; Cvetkovic B.Z. [ 7 ] ; Dittrich P. S. [ 7 ] ; Vasovic N. [ 8 ] ; Duane R. [ 8 ] ; Jaksic A. [ 8 ] ; Zacheo A. [ 1,9 ] ; Zizzari A. [ 1 ] ; Marra L. [ 1 ] ; Perrone E. [ 1 ] ; Salvadori P. A. [ 2 ] ; Rinaldi R. [ 1,9 ]/titolo:Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals/doi:10.1039%2Fc3lc00055a/rivista:Lab on a chip (Print)/anno:2013/pagina_da:2328/pagina_a:2336/intervallo_pagine:2328–2336/volume:13
- Accession number :
- edsair.doi.dedup.....8a01d6f1319cde38a9f66dd3093a01eb