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Role of Interleukin-6 in Development of Insulin Resistance and Type 2 Diabetes Mellitus
- Source :
- Critical Reviews in Eukaryotic Gene Expression. 27:229-236
- Publication Year :
- 2017
- Publisher :
- Begell House, 2017.
-
Abstract
- Interleukin-6 (IL-6) is a proinflammatory cytokine that decisively induces the development of insulin resistance and pathogenesis of type 2 diabetes mellitus (T2DM) through the generation of inflammation by controlling differentiation, migration, proliferation, and cell apoptosis. The presence of IL-6 in tissues is a normal consequence, but its irregular production and long-term exposure leads to the development of inflammation, which induces insulin resistance and overt T2DM. There is a mechanistic relationship between the stimulation of IL-6 and insulin resistance. IL-6 causes insulin resistance by impairing the phosphorylation of insulin receptor and insulin receptor substrate-1 by inducing the expression of SOCS-3, a potential inhibitor of insulin signaling. In this article, we have briefly described how IL-6 induces the insulin resistance and pathogenesis of T2DM. The prevention of inflammatory disorders by blocking IL-6 and IL-6 signaling may be an effective strategy for the treatment of insulin resistance and T2DM.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
endocrine system diseases
Apoptosis
Inflammation
Proinflammatory cytokine
Pathogenesis
03 medical and health sciences
Insulin resistance
Diabetes mellitus
Internal medicine
Genetics
Humans
Insulin
Medicine
Interleukin 6
Molecular Biology
Cell Proliferation
biology
Interleukin-6
business.industry
Type 2 Diabetes Mellitus
medicine.disease
Receptor, Insulin
Insulin receptor
030104 developmental biology
Endocrinology
Diabetes Mellitus, Type 2
Gene Expression Regulation
Suppressor of Cytokine Signaling 3 Protein
Insulin Receptor Substrate Proteins
biology.protein
Insulin Resistance
medicine.symptom
business
Signal Transduction
Subjects
Details
- ISSN :
- 10454403
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Critical Reviews in Eukaryotic Gene Expression
- Accession number :
- edsair.doi.dedup.....89fdbbed743cf94260418fc0510a5c1b