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Exploring the Links between Diet and Health in an Irish Cohort: A Lipidomic Approach
- Source :
- Journal of Proteome Research. 16:1280-1287
- Publication Year :
- 2017
- Publisher :
- American Chemical Society (ACS), 2017.
-
Abstract
- Epidemiology and clinical studies provide clear evidence of the complex links between diet and health. To understand these links, reliable dietary assessment methods are pivotal. Biomarkers have emerged as more objective measures of intake compared with traditional dietary assessment methods. However, there are only a limited number of putative biomarkers of intake successfully identified and validated. The use of biomarkers that reflect food intake to examine diet related diseases represents the next step in biomarker research. Therefore, the aim of this study was to (1) identify and confirm biomarkers associated with dietary fat intake and (2) examine the relationship between those biomarkers with health parameters. Heatmap analysis identified a panel of 22 lipid biomarkers associated with total dietary fat intake in the Metabolic Challenge (MECHE) Study. Confirmation of four of these biomarkers demonstrated responsiveness to different levels of fat intake in a separate intervention study (NutriTech study). Linear regression identified a significant relationship between the panel of dietary fat biomarkers and HOMA-IR, with three lipid biomarkers (C16, PCaaC36:2, and PCae36:4) demonstrating significant associations. Identifying such links allows us to explore the relationship between diet and health to determine whether these biomarkers can be modulated through diet to improve health outcomes. Department of Agriculture, Food and the Marine
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Food intake
Adolescent
Dietary assessment
Diseases
Biology
Biochemistry
Cohort Studies
Eating
Young Adult
03 medical and health sciences
Internal medicine
Environmental health
Epidemiology
medicine
Humans
Dietary biomarkers
2. Zero hunger
Total Dietary Fat
General Chemistry
Middle Aged
medicine.disease
Metabolic syndrome
Dietary Fats
Lipids
Diet
3. Good health
030104 developmental biology
Endocrinology
Health
Lipidomics
Cohort
Biomarker (medicine)
Female
Lipid biomarkers
Ireland
Biomarkers
Dietary fat
Subjects
Details
- ISSN :
- 15353907 and 15353893
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Journal of Proteome Research
- Accession number :
- edsair.doi.dedup.....89f42749ad3f36171746e67e8b17133e