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Comparable outcomes for patients with pT1a and pT1b differentiated thyroid cancer: Is there a need for change in the AJCC classification system?
- Source :
- Surgery. 156:1484-1490
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Introduction The current American Joint Committee on Cancer TNM classification for differentiated thyroid cancer (DTC) separates T1 status into T1a and T1b based on a 1-cm cutoff for maximal tumor dimension. In 2009, the American Thyroid Association recommended total thyroidectomy for tumors >1 cm in contrast to the possibility of lobectomy for tumors ≤1 cm. Our aim was to investigate the prognostic significance of a 1-cm tumor cutoff. Methods From an institutional database of 3,664 patients with DTC, 1,522 patients with T1 tumors without neck disease or distant metastases were identified. Patient, tumor, and treatment characteristics were compared. Disease-specific survival (DSS) and recurrence-free survival (RFS) outcomes were analyzed. Results Total thyroidectomy rates were similar between patients with T1a and T1b tumors (P = .307). With a median follow-up of 46 months (range, 1–320), there were no disease-specific deaths in the T1a or T1b groups. In total, 18 patients (1.2%) experienced a recurrence. Five-year RFS was comparable for patients with T1a and T1b tumors (98.6 vs 98.6%; P = .224). Conclusion T1a and T1b tumors have similar prognosis both in terms of DSS and RFS. It seems that a distinction between tumors of 1 cm is of no prognostic benefit.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Time Factors
Databases, Factual
Advisory Committees
Neck disease
Disease-Free Survival
Internal medicine
Humans
Medicine
Neoplasm Invasiveness
Thyroid Neoplasms
Thyroid cancer
Aged
Neoplasm Staging
Retrospective Studies
Aged, 80 and over
Total thyroidectomy
business.industry
Biopsy, Needle
Thyroid
Cancer
Middle Aged
Prognosis
medicine.disease
Immunohistochemistry
Treatment characteristics
United States
Surgery
Survival Rate
medicine.anatomical_structure
Thyroidectomy
Female
business
Needs Assessment
Subjects
Details
- ISSN :
- 00396060
- Volume :
- 156
- Database :
- OpenAIRE
- Journal :
- Surgery
- Accession number :
- edsair.doi.dedup.....89f3b08b1ce61b0708aa41855f16274c