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In-vitro examination of the positive inotropic effect of caffeine and taurine, the two most frequent active ingredients of energy drinks
- Source :
- BMC Cardiovascular Disorders, Vol 17, Iss 1, Pp 1-8 (2017), BMC Cardiovascular Disorders
- Publication Year :
- 2017
- Publisher :
- BMC, 2017.
-
Abstract
- Background Our study aimed to evaluate changes in the contractile behavior of human myocardium after exposure to caffeine and taurine, the main active ingredients of energy drinks (EDs), and to evaluate whether taurine exhibits any inotropic effect at all in the dosages commonly used in EDs. Methods Myocardial tissue was removed from the right atrial appendages of patients undergoing cardiac surgery and prepared to obtain specimens measuring 4 mm in length. A total of 92 specimens were exposed to electrical impulses at a frequency of 75 bpm for at least 40 min to elicit their maximum contractile force before measuring the isometric contractile force (ICF) and duration of contraction (CD). Following this, each specimen was treated with either taurine (group 1, n = 29), or caffeine (group 2, n = 31) or both (group 3, n = 32). After exposure, ICF and CD measuring were repeated. Post-treatment values were compared with pre-treatments values and indicated as percentages. Results Exposure to taurine did not alter the contraction behavior of the specimens. Exposure to caffeine, in contrast, led to a significant increase in ICF (118 ± 03%, p
- Subjects :
- 0301 basic medicine
Inotrope
medicine.medical_specialty
Taurine
lcsh:Diseases of the circulatory (Cardiovascular) system
Cardiotonic Agents
Time Factors
Contraction (grammar)
Dose
Energy drinks
Isometric exercise
In Vitro Techniques
Contractile force
03 medical and health sciences
chemistry.chemical_compound
Internal medicine
Caffeine
medicine
Humans
Atrial Appendage
Duration of contraction
Aged
Active ingredient
030109 nutrition & dietetics
business.industry
Cardiac Pacing, Artificial
Positive inotropic effect
Correction
Middle Aged
Myocardial Contraction
In vitro
Endocrinology
chemistry
lcsh:RC666-701
Anesthesia
Cardiology and Cardiovascular Medicine
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712261
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Cardiovascular Disorders
- Accession number :
- edsair.doi.dedup.....89f0692eaed640f73ca99d34eb1cc84a