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Implications of Postoperative Complications for Survival After Cytoreductive Surgery and HIPEC: A Multi-Institutional Analysis of the US HIPEC Collaborative
- Source :
- Annals of surgical oncology, vol 27, iss 13, Ann Surg Oncol
- Publication Year :
- 2020
- Publisher :
- eScholarship, University of California, 2020.
-
Abstract
- BackgroundPostoperative complications (POCs) are associated with worse oncologic outcomes in various cancer histologies. The impact of POCs on thesurvivalof patients withappendiceal or colorectal cancer after cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) is unknown.MethodsThe US HIPEC Collaborative (2000-2017) was reviewed for patients who underwent CCR0/1 CRS/HIPEC for appendiceal/colorectal cancer. The analysis was stratified by noninvasive appendiceal neoplasm versus invasive appendiceal/colorectal adenocarcinoma. The POCs were grouped into infectious, cardiopulmonary, thromboembolic, and intestinal dysmotility. The primary outcomes were overall survival (OS) and recurrence-free survival (RFS).ResultsOf the 1304 patients, 33% had noninvasive appendiceal neoplasm (n = 426), and 67% had invasive appendiceal/colorectal adenocarcinoma (n = 878). In the noninvasive appendiceal cohort, POCs were identified in 55% of the patients (n = 233). The 3-year OS and RFS did not differ between the patients who experienced a complication and those who did not (OS, 94% vs 94%, p = 0.26; RFS, 68% vs 60%, p = 0.15). In the invasive appendiceal/colorectal adenocarcinoma cohort, however, POCs (63%; n = 555) were associated with decreased 3-year OS (59% vs 74%; p
- Subjects :
- Male
medicine.medical_specialty
Colorectal cancer
Oncology and Carcinogenesis
Hyperthermic Intraperitoneal Chemotherapy
Gastroenterology
Article
03 medical and health sciences
0302 clinical medicine
Postoperative Complications
Clinical Research
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Oncology & Carcinogenesis
Survival rate
Peritoneal Neoplasms
Retrospective Studies
Aged
Cancer
business.industry
Hazard ratio
Retrospective cohort study
Cytoreduction Surgical Procedures
Middle Aged
medicine.disease
Colo-Rectal Cancer
Survival Rate
Good Health and Well Being
Oncology
Appendiceal Neoplasms
030220 oncology & carcinogenesis
Peritoneal Cancer Index
030211 gastroenterology & hepatology
Surgery
Hyperthermic intraperitoneal chemotherapy
Female
Complication
business
Digestive Diseases
Subjects
Details
- ISSN :
- 20002017
- Database :
- OpenAIRE
- Journal :
- Annals of surgical oncology, vol 27, iss 13, Ann Surg Oncol
- Accession number :
- edsair.doi.dedup.....89efeaf5db7940eae6624799d1651c42