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Diagnostic Performance of Magnetic Resonance Imaging for Preoperative Local Staging of Penile Cancer: A Systematic Review and Meta-Analysis
- Source :
- Applied Sciences, Vol 11, Iss 7090, p 7090 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Invasion of the tunica albuginea (TA) and/or urethra are key factors in determining the feasibility of organ-preserving surgery in penile cancer (PC). Magnetic resonance imaging (MRI) appeared to be a promising technique for preoperative local staging. We performed a systematic review (SR) and pooled meta-analysis to investigate the diagnostic performance of MRI in preoperative local staging of primary PC. An SR up to May 2021 was performed according to the PRISMA statement. The diagnostic performance of MRI was evaluated according to TA invasion, urethra invasion, and pT-stage ≥ 2. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) from eligible studies were pooled and summary receiver operating characteristic (SROC) curves were constructed. Overall, seven qualified studies were deemed suitable. Diagnostic performance of MRI showed an accuracy of 0.89 for TA invasion (sensitivity 0.78, PPV 0.79, specificity 0.91, and NPV 0.90); an accuracy of 0.88 for urethra invasion (sensitivity 0.65, PPV 0.46, specificity 0.86, and NPV 0.93); an accuracy of 0.90 for pT ≥ 2 (sensitivity 0.86, PPV 0.84, specificity 0.70, and NPV 0.73).Currently available evidence indicates that MRI might be a one-stop shop for local staging of primary PC and play a central role with regard to conservative surgical management.
- Subjects :
- medicine.medical_specialty
Technology
magnetic resonance imaging
organ sparing surgery
penile amputation
penile neoplasms
radical penectomy
QH301-705.5
QC1-999
Penile Neoplasm
030232 urology & nephrology
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
medicine
Penile cancer
General Materials Science
Biology (General)
Instrumentation
QD1-999
Fluid Flow and Transfer Processes
medicine.diagnostic_test
Receiver operating characteristic
business.industry
Process Chemistry and Technology
Physics
General Engineering
Magnetic resonance imaging
medicine.disease
Engineering (General). Civil engineering (General)
Predictive value
Computer Science Applications
Chemistry
Urethra
medicine.anatomical_structure
Key factors
Meta-analysis
Radiology
TA1-2040
business
Subjects
Details
- Language :
- English
- ISSN :
- 20763417
- Volume :
- 11
- Issue :
- 7090
- Database :
- OpenAIRE
- Journal :
- Applied Sciences
- Accession number :
- edsair.doi.dedup.....89eb4c95ea38bae8d6124673b03563b8