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Diagnostic Performance of Magnetic Resonance Imaging for Preoperative Local Staging of Penile Cancer: A Systematic Review and Meta-Analysis

Authors :
Rocco Simone Flammia
Pierre I. Karakiewicz
Z. Tian
Luca Antonelli
Arianna Bernardotto
Antonio Tufano
Valeria Panebianco
Alberto Andres Castro Bigalli
Costantino Leonardo
Marc C. Smaldone
Source :
Applied Sciences, Vol 11, Iss 7090, p 7090 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Invasion of the tunica albuginea (TA) and/or urethra are key factors in determining the feasibility of organ-preserving surgery in penile cancer (PC). Magnetic resonance imaging (MRI) appeared to be a promising technique for preoperative local staging. We performed a systematic review (SR) and pooled meta-analysis to investigate the diagnostic performance of MRI in preoperative local staging of primary PC. An SR up to May 2021 was performed according to the PRISMA statement. The diagnostic performance of MRI was evaluated according to TA invasion, urethra invasion, and pT-stage ≥ 2. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) from eligible studies were pooled and summary receiver operating characteristic (SROC) curves were constructed. Overall, seven qualified studies were deemed suitable. Diagnostic performance of MRI showed an accuracy of 0.89 for TA invasion (sensitivity 0.78, PPV 0.79, specificity 0.91, and NPV 0.90); an accuracy of 0.88 for urethra invasion (sensitivity 0.65, PPV 0.46, specificity 0.86, and NPV 0.93); an accuracy of 0.90 for pT ≥ 2 (sensitivity 0.86, PPV 0.84, specificity 0.70, and NPV 0.73).Currently available evidence indicates that MRI might be a one-stop shop for local staging of primary PC and play a central role with regard to conservative surgical management.

Details

Language :
English
ISSN :
20763417
Volume :
11
Issue :
7090
Database :
OpenAIRE
Journal :
Applied Sciences
Accession number :
edsair.doi.dedup.....89eb4c95ea38bae8d6124673b03563b8