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Does the polymorphism in the length of the polyalanine tract of FOXE1 gene influence the risk of thyroid dysgenesis occurrence?
- Source :
- Repositório Digital do Instituto Evandro Chagas (Patuá), Instituto Evandro Chagas (IEC), instacron:IEC, Journal of Thyroid Research, Vol 2017 (2017)
- Publication Year :
- 2017
- Publisher :
- Hindawi Publishing Corporation, 2017.
-
Abstract
- Funda??o de Amparo ? Pesquisa do Estado do Par? (FAPESPA, Grant no. 236/2009); ? Capacita??o e Aperfei?oamento de Pessoal de Ensino Superior (CAPES), Instituto Nacional de Gen?tica M?dica Populacional (Edital de Gen?tica Cl?nica/CNPq, Grant no. 402050/2010-0); and Conselho Nacional de Desenvolvimento Cient??fico e Tecnol?gico (CNPq, Grant no. 573993/2008-4). Universidade Federal do Par?. Instituto de Ci?ncias Fisiol?gicas. Laborat?rio de Erros Inatos do Metabolismo. Bel?m, PA, Brazil. Universidade Federal do Par?. Instituto de Ci?ncias Fisiol?gicas. Laborat?rio de Erros Inatos do Metabolismo. Bel?m, PA, Brazil / Universidade do Estado do Par?. Departamento de Morfologia e Ci?ncias Fisiol?gicas. Bel?m, PA, Brazil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Laborat?rio de Cultura de Tecidos e Citogen?tica. Ananindeua, PA, Brasil / Universidade Federal do Par?. Instituto de Ci?ncias Exatas e Naturais. Bel?m, PA, Brazil. Universidade Federal do Par?. Instituto de Ci?ncias Fisiol?gicas. Laborat?rio de Erros Inatos do Metabolismo. Bel?m, PA, Brazil. Background. Recent data have suggested that polymorphisms in the length of the polyalanine tract (polyA) of FOXE1 gene may act as a susceptibility factor for thyroid dysgenesis. The main purpose of this study was to investigate the influence of polyA of FOXE1 gene on the risk of thyroid dysgenesis. Method. A case-control study was conducted in a sample of 90 Brazilian patients with thyroid dysgenesis and 131 controls without family history of thyroid disease. Genomic DNA was isolated from peripheral blood samples and the genotype of each individual was determined by automated sequencing. Results. More than 90% of genotypes found in the group of patients with thyroid dysgenesis and in controls subjects were represented by sizes 14 and 16 polymorphisms in the following combinations: 14/14, 14/16, and 16/16. Genotypes 14/16 and 16/16 were more frequent in the control group, while genotype 14/14 was more frequent in the group of patients with thyroid dysgenesis. There was no difference between agenesis group and control group. Genotype 14/14 when compared to genotypes 14/16 and 16/16A showed an association with thyroid dysgenesis. Conclusion. PolyA of FOXE1 gene alters the risk of thyroid dysgenesis, which may explain in part the etiology of this disease.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Article Subject
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Gl?ndula Tireoide / diagn?stico
Disease
Thyroid dysgenesis
lcsh:Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
Polimorfismo Gen?tico
0302 clinical medicine
Internal medicine
Genotype
medicine
Family history
lcsh:RC648-665
business.industry
Thyroid disease
medicine.disease
genomic DNA
030104 developmental biology
Endocrinology
Doen?as da Gl?ndula Tireoide
Agenesis
Etiology
Hipotireoidismo Cong?nito
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Repositório Digital do Instituto Evandro Chagas (Patuá), Instituto Evandro Chagas (IEC), instacron:IEC, Journal of Thyroid Research, Vol 2017 (2017)
- Accession number :
- edsair.doi.dedup.....89e891eb00d9b0769d12f0ddf9f0a044