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Sexual Dimorphism of Resting-State Network Connectivity in Healthy Ageing
Sexual Dimorphism of Resting-State Network Connectivity in Healthy Ageing
- Source :
- J Gerontol B Psychol Sci Soc Sci
- Publication Year :
- 2018
- Publisher :
- Oxford University Press (OUP), 2018.
-
Abstract
- ObjectivesThe onset of many illnesses is confounded with age and sex. Increasing age is a risk factor for the development of many illnesses, and sexual dimorphism influences brain anatomy, function, and cognition. Here, we examine frequency-specific connectivity in resting-state networks in a large sample (n = 406) of healthy aged adults.MethodWe quantify frequency-specific connectivity in three resting-state networks known to be implicated in age-related decline: the default mode, dorsal attention, and salience networks, using multiband functional magnetic resonance imaging. Frequency-specific connectivity was quantified in four bands: low (0.015–0.027 Hz), moderately low (0.027–0.073 Hz), moderately high (0.073–0.198 Hz), and high (0.198–0.5 Hz) frequency bands, using mean intensity and spatial extent. Differences in connectivity between the sexes in each of the three networks were examined.ResultsEach network showed the largest intensity and spatial extent at low frequencies and smallest extent at high frequencies. Males showed greater connectivity than females in the salience network. Females showed greater connectivity than males in the default mode network.DiscussionResults in this healthy aged cohort are compatible with those obtained in young samples, suggesting that frequency-specific connectivity, and differences between the sexes, are maintained into older age. Our results indicate that sex should be considered as an influencing factor in studies of resting-state connectivity.
- Subjects :
- Male
Aging
medicine.medical_specialty
Social Psychology
Audiology
Biology
The Journal of Gerontology: Psychological Sciences
050105 experimental psychology
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Thalamus
Cerebellum
Connectome
medicine
Humans
Multicenter Studies as Topic
0501 psychology and cognitive sciences
Risk factor
Default mode network
Aged
Randomized Controlled Trials as Topic
Aged, 80 and over
Cerebral Cortex
medicine.diagnostic_test
Resting state fMRI
05 social sciences
Cognition
Magnetic Resonance Imaging
Sexual dimorphism
Clinical Psychology
Cohort
Female
Nerve Net
Geriatrics and Gerontology
Functional magnetic resonance imaging
Gerontology
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 17585368 and 10795014
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- The Journals of Gerontology: Series B
- Accession number :
- edsair.doi.dedup.....89da13f0c6c20c0b73031121a9423419
- Full Text :
- https://doi.org/10.1093/geronb/gby004