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Muscarinic receptors control markers of inflammation in the small intestine of BALB/c mice
- Source :
- Journal of neuroimmunology. 362
- Publication Year :
- 2021
-
Abstract
- Muscarinic-acetylcholine-receptors (mAChRs) modulate intestinal homeostasis, but their role in inflammation is unclear; thus, this issue was the focus of this study. BALB/c mice were treated for 7 days with muscarine (mAChR/agonist), atropine (mAChR/antagonist) or saline. Small-intestine samples were collected for histology and cytofluorometric assays in Peyer's patches (PP) and lamina propria (LP) cell-suspensions. In LP, goblet-cells/leukocytes/neutrophils/MPO+ cells and MPO/activity were increased in the muscarine group. In PP, IFN-γ+/CD4+ T or IL-6+/CD4+ T cell numbers were higher in the muscarine or atropine groups, respectively. In LP, TNF-α+/CD4+ T cell number was higher in the muscarine group and lower in the atropine.
- Subjects :
- Agonist
CD4-Positive T-Lymphocytes
medicine.medical_specialty
medicine.drug_class
T cell
Immunology
Muscarinic Agonists
BALB/c
chemistry.chemical_compound
Mice
Peyer's Patches
Internal medicine
Muscarinic acetylcholine receptor
Intestine, Small
medicine
Immunology and Allergy
Animals
Intestinal Mucosa
Inflammation
Lamina propria
Mice, Inbred BALB C
Muscarine
biology
Chemistry
biology.organism_classification
Receptors, Muscarinic
Atropine
medicine.anatomical_structure
Endocrinology
Neurology
Myeloperoxidase
biology.protein
Neurology (clinical)
medicine.drug
Subjects
Details
- ISSN :
- 18728421
- Volume :
- 362
- Database :
- OpenAIRE
- Journal :
- Journal of neuroimmunology
- Accession number :
- edsair.doi.dedup.....89bdb0b465edda3b5e8424ecc6abf503