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Visualization and Non-Destructive Quantification of Inkjet-Printed Pharmaceuticals on Different Substrates Using Raman Spectroscopy and Raman Chemical Imaging
- Source :
- Pharmaceutical Research. 34:1023-1036
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- The purpose of this study was to investigate the applicability of Raman spectroscopy for visualization and quantification of inkjet-printed pharmaceuticals. Haloperidol was used as a model active pharmaceutical ingredient (API), and a printable ink base containing lactic acid and ethanol was developed. Inkjet printing technology was used to apply haloperidol ink onto three different substrates. Custom-made inorganic compacts and dry foam, as well as marketed paracetamol tablets were used as the substrates. Therapeutic personalized doses were printed by using one to ten printing rounds on the substrates. The haloperidol content in the finished dosage forms were determined by high-performance liquid chromatography (HPLC). The distribution of the haloperidol on the dosage forms were visualized using Raman chemical imaging combined with principal components analysis (PCA). Raman spectroscopy combined with modeling by partial least squares (PLS) regression was used for establishment of a quantitative model of the haloperidol content in the printed dosage forms. A good prediction of the haloperidol content was achieved for the inorganic compacts, while a slightly poorer prediction was observed for the paracetamol tablets. It was not possible to quantify haloperidol on the dry foam due to the low and varying density of the substrate. Raman spectroscopy is a useful tool for visualization and quality control of inkjet printed personalized medicine.
- Subjects :
- Quality Control
Chemical imaging
Materials science
Analytical chemistry
Pharmaceutical Science
02 engineering and technology
Substrate (printing)
Spectrum Analysis, Raman
030226 pharmacology & pharmacy
High-performance liquid chromatography
Dosage form
03 medical and health sciences
symbols.namesake
0302 clinical medicine
Partial least squares regression
Technology, Pharmaceutical
Pharmacology (medical)
Lactic Acid
Least-Squares Analysis
Precision Medicine
Chromatography, High Pressure Liquid
Dosage Forms
Pharmacology
Active ingredient
Principal Component Analysis
Chromatography
Ethanol
Inkwell
Organic Chemistry
021001 nanoscience & nanotechnology
Pharmaceutical Preparations
symbols
Haloperidol
Printing
Molecular Medicine
0210 nano-technology
Raman spectroscopy
Tablets
Biotechnology
Subjects
Details
- ISSN :
- 1573904X and 07248741
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical Research
- Accession number :
- edsair.doi.dedup.....89a670b2de44bf60f2f3c388a838de55