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Ionizing radiation, ion transports and radioresistance of cancer cells
- Source :
- Frontiers in Physiology, Vol 4 (2013), Frontiers in Physiology
- Publication Year :
- 2013
- Publisher :
- Frontiers Media S.A., 2013.
-
Abstract
- The standard treatment of many tumor entities comprises fractionated radiation therapy which applies ionizing radiation to the tumor-bearing target volume. Ionizing radiation causes double-strand breaks in the DNA backbone that result in cell death if the number of DNA double-strand breaks exceeds the DNA repair capacity of the tumor cell. Ionizing radiation reportedly does not only act on the DNA in the nucleus but also on the plasma membrane. In particular, ionizing radiation-induced modifications of ion channels and transporters have been reported. Importantly, these altered transports seem to contribute to the survival of the irradiated tumor cells. The present review article summarizes our current knowledge on the underlying mechanisms and introduces strategies to radiosensitize tumor cells by targeting plasma membrane ion transports.
- Subjects :
- Genetics
DNA Repair
cell migration
lcsh:QP1-981
Physiology
DNA repair
medicine.medical_treatment
cell cycle control
Review Article
Cell cycle
Biology
radiation therapy
Ion Channels
lcsh:Physiology
Ionizing radiation
Radiation therapy
Chromatin remodeling
Physiology (medical)
Radioresistance
Cancer cell
medicine
Cancer research
cell cycle
Irradiation
Ion channel
Subjects
Details
- Language :
- English
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Frontiers in Physiology
- Accession number :
- edsair.doi.dedup.....89989376ca9ea6688fdcc56989095c68