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Examining the gender difference in the association between metabolic syndrome and the mean leukocyte telomere length
- Source :
- PLoS ONE, PLoS ONE, Vol 12, Iss 7, p e0180687 (2017)
- Publication Year :
- 2017
-
Abstract
- The mechanism of cellular aging likely involves decreased telomere length and is associated with age-related diseases such as cardiovascular disease. Metabolic syndrome (MetS) is an important risk factor for CVD. The purpose of this study was to investigate the association between LTL and MetS. We evaluated 7370 participants in the National Health and Nutrition Examination Survey (1999-2002). The association between LTL and individual MetS components and the number of MetS components was analyzed by multivariable regression models, adjusting for gender, race/ethnicity, albumin, C-reactive protein, alanine transaminase, uric acid and medical condition. An increase in the number of MetS components was strongly associated with shorter telomere length, especially in female participants (p for trend < 0.05). In addition, triglycerides were negatively associated with LTL in female participants (p < 0.001). Waist circumstance was associated with decreased LTL (p < 0.05) in both males and females. In summary, our study indicated that an increment of MetS component is strongly associated with shorter LTL, especially in the female population.
- Subjects :
- 0301 basic medicine
Male
lcsh:Medicine
Blood Pressure
030204 cardiovascular system & hematology
Vascular Medicine
Biochemistry
White Blood Cells
0302 clinical medicine
Animal Cells
Leukocytes
Medicine and Health Sciences
Coronary Heart Disease
lcsh:Science
Telomere Length
Genetics
Metabolic Syndrome
Sex Characteristics
Multidisciplinary
Chromosome Biology
Middle Aged
Telomere
C-Reactive Proteins
Chemistry
C-Reactive Protein
Cholesterol
Telomeres
Cardiovascular Diseases
Physical Sciences
Female
Cellular Types
Sex characteristics
Research Article
Adult
medicine.medical_specialty
Chromosome Structure and Function
Waist
National Health and Nutrition Examination Survey
Immune Cells
Immunology
Cardiology
Biology
Chromosomes
03 medical and health sciences
Telomere Homeostasis
Internal medicine
medicine
Humans
Risk factor
Aged
Blood Cells
C-reactive protein
lcsh:R
Chemical Compounds
Biology and Life Sciences
Proteins
Cell Biology
medicine.disease
Uric Acid
030104 developmental biology
Endocrinology
Alanine transaminase
Metabolic Disorders
biology.protein
lcsh:Q
Metabolic syndrome
Acids
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....899814650b008a5934873aceb623e74b