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The fatty acid pattern of triglycerides in liver, adipose tissue and serum of diabetics with hyperlipoproteinemia before and during clofibrate treatment
- Source :
- Acta Diabetologica Latina. 15:40-52
- Publication Year :
- 1978
- Publisher :
- Springer Science and Business Media LLC, 1978.
-
Abstract
- In 20 diabetic inpatients with type IIb, III, IV and V hyperlipoproteinemia (HPL) the triglyceride fatty acid pattern (TFAP) of serum, adipose tissue and liver biopsy specimens before and after one year of clofibrate treatment has been determined by gas-liquid chromatography. Compared to previous results which revealed a correlation between fat droplet size and the TFAP in liver parenchyma cells, remarkable changes were observed after long-term therapy. In adipose tissue, only linoleic acid increased significantly from 8.6 to 11.3%. In serum, myristic and palmitic acid decreased, whereas linoleic, eicosatetraenoic (arachidonic) and eicosapentaenoic acid rose significantly. In liver fat, palmitic acid decreased, whereas linoleic, eicosatrienoic, arachidonic and eicosapentaenoic acid significantly increased. After clofibrate therapy, the TFAP in diabetic subjects with HLP became similar to that of diabetics without HLP. The most pronounced changes were found in the liver, serum having an intermediate position between liver and adipose tissue. The pathophysiological relevance in view of possible relations to prostaglandins has been discussed.
- Subjects :
- Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Linoleic acid
Adipose tissue
Hyperlipidemias
Diabetes Complications
Palmitic acid
chemistry.chemical_compound
Endocrinology
Internal medicine
Diabetes Mellitus
Internal Medicine
medicine
Humans
Clofibrate
Triglycerides
chemistry.chemical_classification
medicine.diagnostic_test
Triglyceride
Chemistry
Fatty Acids
Fatty acid
General Medicine
Middle Aged
Eicosapentaenoic acid
Adipose Tissue
Liver
Liver biopsy
Female
medicine.drug
Subjects
Details
- ISSN :
- 14325233 and 00015563
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Acta Diabetologica Latina
- Accession number :
- edsair.doi.dedup.....89891b3afeca3f891ad7373fd238fdb7
- Full Text :
- https://doi.org/10.1007/bf02581006