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Prevalence and Clinical Characterization of a Newly Identified Human Rhinovirus C Species in Children with Acute Respiratory Tract Infections
- Source :
- Journal of Clinical Microbiology
- Publication Year :
- 2009
- Publisher :
- American Society for Microbiology, 2009.
-
Abstract
- Human rhinovirus C (HRV-C) is a newly identified genotype of HRV found in patients with respiratory tract infections (RTIs); however, its epidemiological profile and clinical characteristics are not well understood. In this study, Chinese children with RTIs were screened for HRV-C and their epidemiological and clinical characteristics were analyzed. From December 2006 to November 2007, 406 nasopharyngeal aspirates from children younger than 14 years of age with RTIs were screened for HRV and other common respiratory viruses by PCR or reverse transcription-PCR. Two-hundred twenty-four (55.2%) of the specimens were infected with at least one virus, including 53 patients with HRV (13%). HRV-A, HRV-B, and HRV-C were detected in 22, 12, and 19 specimens, respectively. HRV-C was detected mainly from December 2006 to April 2007 and from October to November 2007, with peaks in December and April (10/19). Acute upper respiratory infection and bronchopneumonia were observed in 53 and 37% of the cases, respectively. The most common symptoms were cough (82%), runny nose (53%), and fever (37%). Wheezing and bronchiolitis were less common in patients infected with HRV-C than in those infected with respiratory syncytial virus (RSV). Partial sequencing of the genes coding for VP4 and VP2 revealed that the HRV-C strains were 56 to 62% identical at the amino acid level to HRV-B and HRV-A reference strains and 80 to 99% identical to HRV-C reference strains. In conclusion, HRV-C is an important cause of RTIs in children, and highly diversified strains of HRV-C are prevalent in China. HRV-C may produce different epidemiological features, and patients infected with HRV-C may exhibit different clinical features from patients infected with RSV or HRV-A/B.
- Subjects :
- Male
Microbiology (medical)
China
Adolescent
Rhinovirus
Molecular Sequence Data
Biology
medicine.disease_cause
Polymerase Chain Reaction
Virus
stomatognathic system
Nasopharynx
Virology
Genotype
Bronchopneumonia
Prevalence
otorhinolaryngologic diseases
medicine
Humans
Child
Respiratory Tract Infections
Phylogeny
Nose
Viral Structural Proteins
Picornaviridae Infections
Sequence Homology, Amino Acid
Respiratory tract infections
Reverse Transcriptase Polymerase Chain Reaction
Respiratory disease
Infant, Newborn
Infant
virus diseases
Sequence Analysis, DNA
medicine.disease
medicine.anatomical_structure
Bronchiolitis
Child, Preschool
Female
Seasons
circulatory and respiratory physiology
Respiratory tract
Subjects
Details
- ISSN :
- 00951137
- Volume :
- 47
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Microbiology
- Accession number :
- edsair.doi.dedup.....8981944e0e13d72c661db92ad908f72a
- Full Text :
- https://doi.org/10.1128/jcm.00745-09