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Autosomal STR and SNP characterization of populations from the Northeastern Peruvian Andes with the ForenSeq™ DNA Signature Prep Kit
- Source :
- Forensic Science International: Genetics. 52:102487
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Autosomal DNA data from Peru for human identity testing purposes are scarce in the scientific literature, which hinders obtaining an appropriate portrait of the genetic variation of the resident populations. In this study we genetically characterize five populations from the Northeastern Peruvian Andes (Chachapoyas, Awajun, Wampis, Huancas and Cajamarca). Autosomal short tandem repeat (aSTR) and identity informative single nucleotide polymorphism (iiSNP) data from a total of 233 unrelated individuals are provided, and forensic genetic parameters are calculated for each population and for the combined set Northeastern Peruvian Andes. After correction for multiple testing in the whole dataset of the Northeastern Peruvian Andes, the only departure from Hardy-Weinberg equilibrium was observed in locus rs2111980. Twenty one out of 27 aSTR loci exhibited an increased number of alleles due to sequence variation in the repeat motif and flanking regions. For iiSNPs 33% of the loci displayed flanking region variation. The combined random match probability (RMP), assuming independence of all loci (aSTRs and iiSNPs), in the Chachapoyas, the population with the largest samples size (N = 172), was 8.14 x 10(-62) for length-based data while for sequence-based was 4.15 x 10(-67). In the merged dataset (Northeastern Peruvian Andes; N = 233), the combined RMP when including all markers were 2.96 x 10(-61) (length-based) and 3.21 x 10(-66) (sequence-based). These new data help to fill up some of the gaps in the genetic canvas of South America and provide essential length- and sequence-based background information for other forensic genetic studies in Peru.
- Subjects :
- 0301 basic medicine
Population
Single-nucleotide polymorphism
Locus (genetics)
Biology
Polymorphism, Single Nucleotide
Pathology and Forensic Medicine
03 medical and health sciences
Autosomal SNPs
0302 clinical medicine
Gene Frequency
Autosomal STRs
Peru
parasitic diseases
Genetic variation
Ethnicity
Genetics
Humans
SNP
030216 legal & forensic medicine
Allele
education
education.field_of_study
Forenseq (TM) Signature Prep Kit
Northeastern Peru
319 Forensic science and other medical sciences
DNA Fingerprinting
Genetics, Population
030104 developmental biology
Evolutionary biology
Multiple comparisons problem
Microsatellite
geographic locations
Microsatellite Repeats
Subjects
Details
- ISSN :
- 18724973
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Forensic Science International: Genetics
- Accession number :
- edsair.doi.dedup.....897ffe5447ac823d94d7e23bec06d9fb