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Unpredictable Performance of pH-Dependent Coatings Accentuates the Need for Improved Predictive in Vitro Test Systems
- Source :
- Molecular pharmaceutics. 14(12)
- Publication Year :
- 2017
-
Abstract
- First introduced in the second half of the 19th century, enteric coatings are commonly used to protect acid-labile drugs, reduce the risk of gastric side effects due to irritating drugs, or for local drug delivery to the lower gastrointestinal (GI) tract. The currently available enteric-coatings are based on pH-sensitive weakly acidic polymers. Despite the long history of their use, the causes behind their performance often being unpredictable have not been properly investigated with most of the attention being focused only on the gastric emptying. However, little attention has been given to the postgastric emptying disintegration and dissolution of these dosage forms. This lack of attention has contributed to the difficulty in predicting the in vivo behavior of these dosage forms and to cases of bioavailability problems with some enteric-coated products. Therefore, increased attention needs to be given to this issue.
- Subjects :
- medicine.medical_specialty
Drug Liberation
In vitro test
Chemistry, Pharmaceutical
Pharmaceutical Science
Ph dependent
Biological Availability
02 engineering and technology
Pharmacology
In Vitro Techniques
030226 pharmacology & pharmacy
Dosage form
Biopharmaceutics
Excipients
03 medical and health sciences
0302 clinical medicine
Drug Discovery
Intestine, Small
medicine
Intensive care medicine
Gastric emptying
business.industry
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
Enteric coating
Bioavailability
Solubility
Drug delivery
Molecular Medicine
Tablets, Enteric-Coated
0210 nano-technology
business
medicine.drug
Subjects
Details
- ISSN :
- 15438392
- Volume :
- 14
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Molecular pharmaceutics
- Accession number :
- edsair.doi.dedup.....897c78ae3a422bbde5b49bf0f99cb813