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Targeting the Cell Membrane by Charge-Reversal Amphiphilic Pillar[5]arene for the Selective Killing of Cancer Cells
- Source :
- ACS Applied Materials & Interfaces. 11:38497-38502
- Publication Year :
- 2019
- Publisher :
- American Chemical Society (ACS), 2019.
-
Abstract
- A charge-reversal amphiphilic pillar[5]arene, P5NH-DCA, bearing 10 charge-reversal headgroups is reported. It targets the cell membrane of cancer cells and selectively destroys the cancer cells by disrupting the membrane. In the acidic tumor microenvironment, the headgroup charge of P5NH-DCA reversed from negative to positive owing to hydrolysis of the acid-labile amide group. The hydrolyzed product bearing multiple positive charges can bind to the cell membrane and then disrupt the membrane of cancer cells with high efficiency. However, under the neutral microenvironment of healthy cells, the negatively charged P5NH-DCA remains stable and the cytotoxicity is considerably reduced. The strategy killing the cancer cells by membrane disruption may represent a new route of cancer chemotherapy.
- Subjects :
- Materials science
Cell Survival
Mice, Nude
Antineoplastic Agents
02 engineering and technology
010402 general chemistry
01 natural sciences
Cell membrane
Mice
chemistry.chemical_compound
Cell Line, Tumor
Neoplasms
Amide
Amphiphile
medicine
Animals
Humans
General Materials Science
Cytotoxicity
Tumor microenvironment
Microscopy, Confocal
Cell Membrane
Pillar
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
0104 chemical sciences
medicine.anatomical_structure
Membrane
chemistry
Cancer cell
Biophysics
Calixarenes
0210 nano-technology
Subjects
Details
- ISSN :
- 19448252 and 19448244
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- ACS Applied Materials & Interfaces
- Accession number :
- edsair.doi.dedup.....896373266f58b214351cc2676bf98f7b