Back to Search
Start Over
The differential expression of EPHB4 and ephrin B2 in cutaneous squamous cell carcinoma according to the grade of tumor differentiation: a clinicopathological study
- Source :
- International journal of dermatologyReferences. 60(6)
- Publication Year :
- 2020
-
Abstract
- BACKGROUND EPHB4 and its ligand, ephrin B2, which are receptor tyrosine kinases of the erythropoietin-producing hepatocellular (EPH) family, are known to be linked to several human cancers. The aim of this study was to investigate their expression patterns in cutaneous squamous cell carcinoma (CSCC) in association with tumor differentiation and other variable clinical characteristics. MATERIALS AND METHODS Immunohistochemical staining for EPHB4 and ephrin B2 was performed in 32 cases of CSCC with different histologic grades. The clinical characteristics and histologic grades of CSCC were evaluated in association with EPHB4 and ephrin B2 expression patterns. RESULTS EPHB4 and ephrin B2 expression levels were significantly inversely proportional to the grade of differentiation of CSCC (P
- Subjects :
- Cutaneous squamous cell carcinoma
Skin Neoplasms
Tumor differentiation
biology
business.industry
Poorly differentiated
Receptor, EphB4
Erythropoietin-producing hepatocellular (Eph) receptor
Cell Differentiation
Ephrin-B2
Dermatology
Receptor tyrosine kinase
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
030220 oncology & carcinogenesis
Cancer research
biology.protein
Carcinoma, Squamous Cell
Immunohistochemistry
Medicine
Humans
Differential expression
business
Ephrin b2
Subjects
Details
- ISSN :
- 13654632
- Volume :
- 60
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- International journal of dermatologyReferences
- Accession number :
- edsair.doi.dedup.....895c48d9003f6f2d5c0e161ed809d5aa