A mouse model of autoimmune encephalitis

Planagumà et al. show that infusing CSF from patients with anti-NMDAR encephalitis into the mouse brain induces progressive memory and behavioural deficits that correlate with levels of brain-bound human NMDAR-antibodies and a reduction in NMDARs. The changes, which are reversible, confirm the pathogenicity of NMDAR-antibodies and have therapeutic implications.