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Autologous versus allogeneic versus umbilical cord sera for the treatment of severe dry eye disease: a double-blind randomized clinical trial
- Source :
- Acta ophthalmologicaReferences. 100(2)
- Publication Year :
- 2021
-
Abstract
- PURPOSE To measure the effects of Autologous serum (AS), Allogeneic Serum (HS) and Umbilical Cord serum (CS) eye drops in severe dry eye disease (DES), as well as to characterize and quantify several molecules in the three sera (albumin, fibronectin; Vitamin A and E; IgG, IgA and IgM; Transforming growth factor β; Epithelial growth factor). METHODS Randomized, double-blind, single-centre, three-arm (AS, HS and CS) clinical trial. Sixty-three subjects were included with severe DES, 21 in each arm of the study. Visual acuity, Schirmer test, Breakup time (BUT), lissamine green, fluorescein staining measurements and a questionnaire were performed prior to treatment, and after one-month and three-month follow-up. RESULTS There was a significant main effect of time on visual acuities, Schirmer and BUT tests and fluorescein and lissamine green staining measurements and questionnaire scores (p = 0.015, p = 0.002, p
- Subjects :
- Vitamin
Male
Serum
medicine.medical_specialty
Visual acuity
Gastroenterology
Umbilical cord
law.invention
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Randomized controlled trial
Double-Blind Method
law
Internal medicine
medicine
Humans
Aged
Autoimmune disease
business.industry
Albumin
General Medicine
Middle Aged
medicine.disease
Staining
Ophthalmology
medicine.anatomical_structure
chemistry
030221 ophthalmology & optometry
Dry Eye Syndromes
Female
medicine.symptom
Ophthalmic Solutions
business
030217 neurology & neurosurgery
Umbilical Cord Serum
Subjects
Details
- ISSN :
- 17553768
- Volume :
- 100
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Acta ophthalmologicaReferences
- Accession number :
- edsair.doi.dedup.....8958a2d7473f2c8139a2792af0573600