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Gastrointestinal and Hepatic Toxicities of Checkpoint Inhibitors: Algorithms for Management
- Source :
- American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 38
- Publication Year :
- 2018
-
Abstract
- Gastrointestinal toxicities are among the leading causes of immune-related adverse effects of checkpoint blockade. These adverse events can be severe enough to require interruption or withdrawal of immune checkpoint blockade therapy. Patients with immune-related adverse effects require early recognition with an evaluation to rule out alternative etiologies and effective management to minimize complications. This article reviews the gastrointestinal and hepatic toxicities of the antibodies that target immune checkpoints CTLA-4 and PD-1/PD-L1 and provides an approach to their diagnosis and management.
- Subjects :
- Diarrhea
Immune checkpoint inhibitors
chemical and pharmacologic phenomena
Bioinformatics
B7-H1 Antigen
03 medical and health sciences
0302 clinical medicine
Immune system
Antineoplastic Agents, Immunological
Biomarkers, Tumor
Medicine
Humans
CTLA-4 Antigen
030212 general & internal medicine
Molecular Targeted Therapy
Adverse effect
biology
business.industry
Liver Diseases
Effective management
General Medicine
Colitis
Immune checkpoint
Blockade
Gastrointestinal Tract
Liver
Pancreatitis
030220 oncology & carcinogenesis
biology.protein
Antibody
business
Liver pathology
Biomarkers
Subjects
Details
- ISSN :
- 15488756
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
- Accession number :
- edsair.doi.dedup.....894b7d48772c5125946bdc6316106d82