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Biodistribution of p-iodobenzoyl (PIP) labeled antibodies in a murine lymphoma model
- Source :
- International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 17(4)
- Publication Year :
- 1990
-
Abstract
- A monoclonal antibody against the murine T-cell antigen Thy 1.1 was radioiodinated using N -succin-imidyl p -iodobenzoate (PIP) in an attempt to decrease deiodination of the labeled antibody. The biodistribution of the PIP labeled antibody was compared to Iodogen labeled antibody in Thy 1.1 + lymphoma bearing AKR/Cum mice, where the antibody was tumor specific, and AKR/J mice where the antibody reacted with both tumor and normal T-cells. PIP labeling resulted in decreased iodine concentrations in stomach and salivary gland as compared to Iodogen labeling. There was little difference in radioiodine concentrations between the two preparations in tumor, lymphoid tissues or other organs. These results suggest deiodination of intact antibody plays little role in the clearance of radioiodinated anti-Thy 1.1 antibody from tissues.
- Subjects :
- Male
medicine.medical_specialty
Biodistribution
Lymphoma
medicine.drug_class
Ratón
Monoclonal antibody
Iodine Radioisotopes
Mice
Mice, Inbred AKR
Antigen
Internal medicine
medicine
Animals
Urea
Tissue Distribution
biology
Salivary gland
Chemistry
Antibodies, Monoclonal
General Medicine
T lymphocyte
medicine.disease
Molecular biology
medicine.anatomical_structure
Endocrinology
Isotope Labeling
biology.protein
Iodobenzoates
Antibody
Neoplasm Transplantation
Subjects
Details
- ISSN :
- 08832897
- Volume :
- 17
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
- Accession number :
- edsair.doi.dedup.....8946492db647ebd524183275fb08980b