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NICORANDIL ATTENUATES NF-??B ACTIVATION, ADHESION MOLECULE EXPRESSION, AND CYTOKINE PRODUCTION IN PATIENTS WITH CORONARY ARTERY BYPASS SURGERY
- Source :
- Shock. 24:103-108
- Publication Year :
- 2005
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2005.
-
Abstract
- Nicorandil (NCR), a KATP channel opener, has been reported to preserve microvascular integrity in patients with reperfused myocardial infarction. We tested the hypothesis that NCR suppresses myocardial ischemia and reperfusion injury via the attenuation of cytokine production. Forty patients who underwent coronary artery bypass graft surgery were studied. The patients were randomly divided into two groups, i.e., the patients with NCR (4-6 mg/h; N group, n = 20) or without NCR (C group, n = 20). Cardiac surgery was performed under anesthesia using fentanyl and propofol. Blood were sampled at the time of induction of anesthesia, pre-cardiopulmonary bypass, 60 min after aortic occlusion, and 60, 120, and 180 min after declamping the aorta. The activation of NF-kappaB, expression of adhesion molecules, and cytokine production were evaluated in blood samples from the control volunteers by flow cytometric analysis with or without lipopolysaccharide (LPS) stimulation in vitro. Serum IL-6 and IL-8 levels in both groups increased 60 min after declamping the aorta compared with the preoperative value (P < 0.001); the increases of these parameters in N group were lower than those in C group (P < 0.05). Serum creatine kinase with muscle and brain subunits and troponin-T levels increased 60 min after declamping the aorta in two groups (P < 0,001), but the increases of both parameters in N group were lower than those in C group (P < 0.05). NF-kappaB activation, CD11b/CD18 expression, and the production of TNF-alpha, IL-8, and IL-6 in monocytes and granulocytes were inhibited by NCR in vitro. NCR suppressed the increase of inflammatory cytokines such as IL-6 and IL-8 levels, and reduced myocardial reperfusion injury. The inhibition on NF-kappaB activation, adhesion molecule expression, and cytokine production may be one of the important mechanisms of myocardial protection of NCR.
- Subjects :
- Lipopolysaccharides
Potassium Channels
Time Factors
Ischemia
Hemodynamics
Pharmacology
Critical Care and Intensive Care Medicine
Monocytes
Coronary artery bypass surgery
Troponin T
Intensive care
medicine.artery
Cell Adhesion
medicine
Humans
Coronary Artery Bypass
Nicorandil
Creatine Kinase
Antihypertensive Agents
Aorta
Interleukin-6
business.industry
Muscles
Myocardium
Interleukin-8
NF-kappa B
Brain
Flow Cytometry
medicine.disease
medicine.anatomical_structure
CD18 Antigens
Reperfusion Injury
Anesthesia
Emergency Medicine
Cytokines
business
Reperfusion injury
Granulocytes
medicine.drug
Artery
Subjects
Details
- ISSN :
- 10732322
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Shock
- Accession number :
- edsair.doi.dedup.....8945732b7a3897fb3fc6812e2661fafc