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IgA-kappa type multiple myeloma affecting proximal and distal renal tubules
- Source :
- Internal medicine (Tokyo, Japan). 40(9)
- Publication Year :
- 2001
-
Abstract
- A 45-year-old male was admitted because of chest pain, lumbago, and bilateral ankle pain. Examination disclosed hypophosphatemic osteomalacia, acquired Fanconi syndrome, and abnormalities in distal nephron such as distal renal tubular acidosis and renal diabetes insipidus. Further exploration revealed IgA kappa multiple myeloma excreting urinary Bence Jones protein (kappa-light chain). Renal biopsy revealed thick basement membranes and elec-tron-dense crystals in proximal tubular epithelial cells. Immunofluorescent studies revealed deposition of kappa-light chain in renal tubular epithelial cells that caused the renal tubular damage. Although the osteomalacia was relieved by medical treatment, the urinary Bence Jones protein and the renal tubular defects were not improved by the chemotherapy for the myeloma. The patient died of exacerbation of multiple myeloma at 50 years of age.
- Subjects :
- Male
medicine.medical_specialty
Pathology
Time Factors
Urinary system
Biopsy
urologic and male genital diseases
Kidney
Kidney Tubules, Proximal
Immunoglobulin kappa-Chains
Fatal Outcome
Distal renal tubular acidosis
Internal medicine
Internal Medicine
medicine
Humans
Kidney Tubules, Distal
Multiple myeloma
medicine.diagnostic_test
business.industry
Fanconi syndrome
General Medicine
Middle Aged
medicine.disease
Bence Jones protein
Kidney Neoplasms
Immunoglobulin A
medicine.anatomical_structure
Endocrinology
Osteomalacia
Renal biopsy
business
Multiple Myeloma
Kidney disease
Subjects
Details
- ISSN :
- 09182918
- Volume :
- 40
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Internal medicine (Tokyo, Japan)
- Accession number :
- edsair.doi.dedup.....89304e16341bb7e4db98260df155cc5a