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Targeting T cell metabolism for immunotherapy
- Source :
- Journal of leukocyte biologyREFERENCES. 110(6)
- Publication Year :
- 2021
-
Abstract
- T cells play an important role in antitumor immunity. Numbers and function of T cells are controlled by regulating the uptake and utilization of nutrients, and their antitumor activity can be promoted by targeting metabolic pathways. In this review, we highlight the relationship between metabolism and cellular function of T cells. Specifically, we emphasize the metabolic state of tumor-infiltrating T cells and review key pathways that affect the antitumor function of T cells. In the field of tumor immunotherapy, targeting T cell metabolism to enhance the immune response is a new therapeutic strategy for enhancing immunotherapy combined with traditional treatments.
- Subjects :
- Antitumor activity
Antitumor immunity
T cell
medicine.medical_treatment
T-Lymphocytes
Immunology
Antineoplastic Agents
Cell Biology
Metabolism
Immunotherapy
Biology
Immunotherapy, Adoptive
Metabolic pathway
Immune system
medicine.anatomical_structure
Lymphocytes, Tumor-Infiltrating
Neoplasms
medicine
Cancer research
Immunology and Allergy
Animals
Humans
Function (biology)
Subjects
Details
- ISSN :
- 19383673
- Volume :
- 110
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of leukocyte biologyREFERENCES
- Accession number :
- edsair.doi.dedup.....891fe562d6fb022ca0a34de9074cb20e