Back to Search
Start Over
Decreased arterial elasticity associated with cardiovascular disease risk factors in the young. Bogalusa Heart Study
- Source :
- Arteriosclerosis: An Official Journal of the American Heart Association, Inc.. 6:378-386
- Publication Year :
- 1986
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1986.
-
Abstract
- Noninvasive ultrasonic examinations were performed in 1984 on a biracial sample of 109 10- to 17-year-old adolescents to determine whether elastic properties of the carotid arteries are associated with cardiovascular disease risk factors in the young. The subjects examined were in either the upper (high risk) or lower (low risk) race-, sex-, and age-specific tertile for both serum total cholesterol (TC) and systolic blood pressure (SBP) during a 1981-82 community survey. The pressure-strain elastic modulus (Ep), a measure of stiffness, for the carotid arteries was calculated by dividing the pulse pressure by the fractional diameter increase in the carotid artery during the cardiac cycle, as measured by ultrasonic techniques. Repeat studies on 20 randomly selected subjects demonstrated high reproducibility of the elasticity measurements (intraclass correlation coefficient = 0.84). The mean Ep in the high risk group was 5.1 kPa higher than in the low risk group, after controlling for race, sex, and age (one-sided p value = 0.03). Furthermore, a positive parental history of myocardial infarction was related to increased Ep levels (p less than 0.05), independently of race, sex, age, TC, and SBP. The results indicate that ultrasonic techniques can detect functional differences in the carotid arteries of children and adolescents that are associated with the risk of cardiovascular disease as adults.
- Subjects :
- Male
Risk
medicine.medical_specialty
Adolescent
Intraclass correlation
Black People
Disease
White People
Sex Factors
Internal medicine
Humans
Medicine
Myocardial infarction
Child
Ultrasonography
Cardiac cycle
business.industry
Arterial elasticity
Louisiana
medicine.disease
Elasticity
Pulse pressure
Surgery
Carotid Arteries
Blood pressure
Cardiovascular Diseases
Disease risk
Cardiology
Female
Vascular Resistance
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 02765047
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
- Accession number :
- edsair.doi.dedup.....890e94789b8a2af613093509bdd9a126
- Full Text :
- https://doi.org/10.1161/01.atv.6.4.378