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Protein and Bacterial Antifouling Behavior of Melt-Coextruded Nanofiber Mats
- Source :
- ACS applied materialsinterfaces. 8(14)
- Publication Year :
- 2016
-
Abstract
- Antifouling surfaces are important for biomedical devices to prevent secondary infections and mitigate the effects of the foreign body response. Herein, we describe melt-coextruded poly(ε-caprolactone) (PCL) nanofiber mats grafted with antifouling polymers. Nonwoven PCL fiber mats are produced using a multilayered melt coextrusion process followed by high-pressure hydroentanglement to yield porous patches. The resulting fiber mats show submicrometer cross-sectional fiber dimensions and yield pore sizes that were nearly uniform, with a mean pore size of 1.6 ± 0.9 μm. Several antifouling polymers, including hydrophilic, zwitterionic, and amphipathic molecules, are grafted to the surface of the mats using a two-step procedure that includes photochemistry followed by the copper-catalyzed azide-alkyne cycloaddition reaction. Fiber mats are evaluated using separate adsorption tests for serum proteins and E. coli. The results indicate that poly(oligo(ethylene glycol) methyl ether methacrylate)-co-(trifluoroethyl methacrylate) (poly(OEGMEMA-co-TFEMA)) grafted mats exhibit approximately 85% less protein adhesion and 97% less E. coli adsorption when compared to unmodified PCL fibermats. In dynamic antifouling testing, the amphiphilic fluorous polymer surface shows the highest flux and highest rejection value of foulants. The work presented within has implications on the high-throughput production of antifouling microporous patches for medical applications.
- Subjects :
- Materials science
Secondary infection
Polyesters
Nanofibers
02 engineering and technology
010402 general chemistry
Methacrylate
01 natural sciences
Polyethylene Glycols
Biofouling
chemistry.chemical_compound
Polymethacrylic Acids
Amphiphile
Cell Adhesion
Escherichia coli
Humans
General Materials Science
Fiber
Composite material
chemistry.chemical_classification
Coinfection
Polymer
Blood Proteins
021001 nanoscience & nanotechnology
0104 chemical sciences
chemistry
Nanofiber
Methacrylates
Adsorption
0210 nano-technology
Ethylene glycol
Hydrophobic and Hydrophilic Interactions
Porosity
Subjects
Details
- ISSN :
- 19448252
- Volume :
- 8
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- ACS applied materialsinterfaces
- Accession number :
- edsair.doi.dedup.....8907914e3795d889ed735d954c7951f0