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Risk Factors, Prognostic Factors, and Nomogram for Distant Metastasis in Breast Cancer Patients Without Lymph Node Metastasis
- Source :
- Frontiers in Endocrinology, Frontiers in Endocrinology, Vol 12 (2021)
- Publication Year :
- 2021
-
Abstract
- BackgroundLymph node negative (N0) breast cancer can be found coexisting with distant metastasis (DM), which might consequently make clinicians underestimate the risk of relapse and insufficient treatment for this subpopulation.MethodsThe clinicopathological characteristics of N0 breast cancer patients from the Surveillance, Epidemiology, and End Results (SEER) database between January 2010 and December 2015 were retrospectively reviewed. Multivariate logistic and Cox analyses were used to identify independent risk factors in promoting DM and the 1-, 3-, and 5- year cancer-specific survival (CSS) in this subpopulation.ResultSeven factors including age (10 mm), race (Black), location (central), grade (poor differentiation), histology (invasive lobular carcinoma), and subtype (luminal B and Her-2 enriched) were associated with DM, and the area under curve (AUC) was 0.776 (95% CI: 0.763–0.790). Moreover, T1-3N0M1 patients with age >60 years at diagnosis, Black race, triple-negative breast cancer subtype, no surgery performed, and multiple DMs presented a worse 1-, 3-, and 5-year CSS. The areas under the ROC for 1-, 3-, and 5- year CSS in the training cohort were 0.772, 0.741, and 0.762, respectively, and 0.725, 0.695, and 0.699 in the validation cohort.ConclusionThe clinicopathological characteristics associated with the risk of DM and the prognosis of female breast cancer patients without lymph node metastasis but with DM are determined. A novel nomogram for predicting 1-, 3-, 5- year CSS in T1-3N0M1 patients is also well established and validated, which could help clinicians better stratify patients who are at a high-risk level for receiving relatively aggressive management.
- Subjects :
- Oncology
Adult
medicine.medical_specialty
N0 breast cancer
Endocrinology, Diabetes and Metabolism
Breast Neoplasms
Lymph node metastasis
Risk Assessment
Diseases of the endocrine glands. Clinical endocrinology
nomogram
Young Adult
Breast cancer
Endocrinology
cancer-specific survival
distant metastasis
Risk Factors
Internal medicine
Epidemiology
medicine
Humans
Risk factor
Neoplasm Metastasis
Aged
Neoplasm Staging
Retrospective Studies
Original Research
business.industry
Age Factors
Distant metastasis
Histology
Nomogram
Middle Aged
medicine.disease
RC648-665
Prognosis
Nomograms
risk factor
Invasive lobular carcinoma
Lymphatic Metastasis
Female
Lymph Nodes
business
Subjects
Details
- ISSN :
- 16642392
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in endocrinology
- Accession number :
- edsair.doi.dedup.....88ffc0caef4cbb3006d758541654fde0