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Genetic causes of nonsyndromic hearing loss in Iran in comparison with other populations
- Source :
- Journal of Human Genetics. 55:639-648
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- Hearing loss (HL) is the most prevalent sensory defect affecting 1 in 500 neonates. Genetic factors are involved in half of the cases. The extreme heterogeneity of HL makes it difficult to analyze and determine the accurate genetic causes of the impairment. Up to now, 10 genes, namely, GJB2, GJB6, SLC26A4, TECTA, PJVK, Col11A2, Myo15A, TMC1, RDX and microRNA (miR-183), have been studied in an Iranian population. The prevalence of HL in Iran was estimated to be 2-3 times higher than that in other parts of the world. Here, the most common bases of congenital nonsyndromic hearing loss (NSHL) are discussed. We reviewed GJB2, GJB6 (large deletion), TECTA, SLC26A4 and PEJVK mutations, and studied their frequencies and distributions in different ethnic groups in 1934, 500, 121, 80 and 34 unrelated families throughout Iran, respectively. GJB2 mutation was the most common factor causing NSHL, with a mean frequency of 18.17% in the Iranian population. The importance of Iran's geographical location in the migration pathway from west to east through the silk route was also highlighted. SLC26A4 and TECTA mutations were the second and third main reasons of HL and accounted for up to 10 and 4% of prelingual HL in Iran, respectively. Mutations in GJB2, SLC26, TECTA and PJVK genes have an important role in HL in Iran and a screening test should be generated for better intervention and diagnosis programs.
- Subjects :
- MYO15A
Hearing loss
Iran
Biology
medicine.disease_cause
Connexins
Iranian population
Gjb2 gene
Gene Frequency
Prevalence
otorhinolaryngologic diseases
Genetics
medicine
Humans
TECTA
Hearing Loss
Allele frequency
Genetics (clinical)
Mutation
Infant, Newborn
Connexin 26
biology.protein
medicine.symptom
GJB6
Subjects
Details
- ISSN :
- 1435232X and 14345161
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Journal of Human Genetics
- Accession number :
- edsair.doi.dedup.....88fa463c72a7a17b8b962e5000dfd8ae