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Controlling Nutritional Status (CONUT) Score is Associated with Overall Survival in Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib: A Multicenter Cohort Study
- Source :
- Nutrients, Volume 12, Issue 4, Nutrients, Vol 12, Iss 1076, p 1076 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- We aimed to investigate the impact of the controlling nutritional status (CONUT) score, an immuno-nutritional biomarker, on the prognosis of patients with hepatocellular carcinoma (HCC) treated with lenvatinib (LEN). This retrospective study enrolled 164 patients with HCC and treated with LEN (median age 73 years, Barcelona Clinic Liver Cancer (BCLC) stage B/C 93/71). Factors associated with overall survival (OS) were evaluated using multivariate and decision tree analyses. OS was calculated using the Kaplan&ndash<br />Meier method and analyzed using the log&ndash<br />rank test. Independent factors for OS were albumin&ndash<br />bilirubin grade 1, BCLC stage B, and CONUT score &lt<br />5 (hazard ratio (HR) 2.9, 95% confidence interval (CI) 1.58&ndash<br />5.31, p &lt<br />0.001). The CONUT score was the most important variable for OS, with OS rates of 70.0% and 29.0% in the low and high CONUT groups, respectively. Additionally, the median survival time was longer in the low CONUT group than in the high CONUT group (median survival time not reached vs. 11.3 months, p &lt<br />0.001). The CONUT score was the most important prognostic variable, rather than albumin&ndash<br />bilirubin grade and BCLC stage, in patients with HCC treated with LEN. Accordingly, immuno-nutritional status may be an important factor in the management of patients with HCC treated with LEN.
- Subjects :
- Male
Prognostic variable
medicine.medical_specialty
Carcinoma, Hepatocellular
Nutritional Status
lcsh:TX341-641
Antineoplastic Agents
lenvatinib
Gastroenterology
Article
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
controlling nutritional status
Medicine
Humans
Nutritional Physiological Phenomena
Aged
Nutrition and Dietetics
business.industry
Phenylurea Compounds
Hazard ratio
Liver Neoplasms
Retrospective cohort study
hepatoma
medicine.disease
Confidence interval
BCLC Stage
Survival Rate
chemistry
Research Design
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Quinolines
030211 gastroenterology & hepatology
Female
prognosis
business
Lenvatinib
lcsh:Nutrition. Foods and food supply
Food Science
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....88f3784ccee2a5d77e52807096509f4f
- Full Text :
- https://doi.org/10.3390/nu12041076