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Intramolecular Cyclization Reaction of Multiple Bonds and Its Application
- Source :
- YAKUGAKU ZASSHI. 131:1437-1443
- Publication Year :
- 2011
- Publisher :
- Pharmaceutical Society of Japan, 2011.
-
Abstract
- The cycloaddition and cycloisomerization of the allene with an alkyne, alkene, or an additional allene for construction of various monocyclic and bicyclic ring systems has been developed. The characteristic features of these methods using allene functionality instead of a simple alkene or alkyne include the reaction mode that originated from the double function as well as the high efficiency for the constructions of medium-sized rings. Furthermore, asymmetric formal synthesis of (+)-nakadomarin A and total synthesis of (+)-fawcettimine and (+)-lycoposerramine-B based on highly stereoselective Pauson-Khand reaction of alkene-alkynes were completed.
- Subjects :
- Pharmacology
chemistry.chemical_classification
Bicyclic molecule
Alkene
Stereochemistry
Allene
Pharmaceutical Science
Alkyne
Total synthesis
Stereoisomerism
Alkenes
Ring (chemistry)
Cycloaddition
Organic Chemistry Phenomena
Alkadienes
chemistry.chemical_compound
Alkaloids
Cycloisomerization
chemistry
Cyclization
Alkynes
Oximes
Heterocyclic Compounds, 3-Ring
Carbolines
Subjects
Details
- ISSN :
- 13475231 and 00316903
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- YAKUGAKU ZASSHI
- Accession number :
- edsair.doi.dedup.....88f34e5f2f1c6cbb7c9fbcf6916abc53