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Spatially offset Raman spectroscopy (SORS) for the analysis and detection of packaged pharmaceuticals and concealed drugs
- Source :
- Forensic Science International. 212:69-77
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Spatially offset Raman spectroscopy (SORS) is a powerful new technique for the non-invasive detection and identification of concealed substances and drugs. Here, we demonstrate the SORS technique in several scenarios that are relevant to customs screening, postal screening, drug detection and forensics applications. The examples include analysis of a multi-layered postal package to identify a concealed substance; identification of an antibiotic capsule inside its plastic blister pack; analysis of an envelope containing a powder; and identification of a drug dissolved in a clear solvent, contained in a non-transparent plastic bottle. As well as providing practical examples of SORS, the results highlight several considerations regarding the use of SORS in the field, including the advantages of different analysis geometries and the ability to tailor instrument parameters and optics to suit different types of packages and samples. We also discuss the features and benefits of SORS in relation to existing Raman techniques, including confocal microscopy, wide area illumination and the conventional backscattered Raman spectroscopy. The results will contribute to the recognition of SORS as a promising method for the rapid, chemically specific analysis and detection of drugs and pharmaceuticals.
- Subjects :
- Illicit Drugs
Computer science
Spatially offset Raman spectroscopy
Forensic Sciences
Street drugs
Plastic bottle
Analytical chemistry
Nanotechnology
Spectrum Analysis, Raman
boats.hull_material
Pathology and Forensic Medicine
Substance Abuse Detection
boats
Drug detection
symbols.namesake
Pharmaceutical Preparations
Wide area
symbols
Humans
Raman spectroscopy
Law
Drug Packaging
Subjects
Details
- ISSN :
- 03790738
- Volume :
- 212
- Database :
- OpenAIRE
- Journal :
- Forensic Science International
- Accession number :
- edsair.doi.dedup.....88f321c428f63e56387c0c92aefe189f