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Evolutionary analysis of foot-and-mouth disease virus serotype SAT 1 isolates from east africa suggests two independent introductions from southern africa
- Source :
- BMC Evolutionary Biology, Vol 10, Iss 1, p 371 (2010), Sangula, A K, Belsham, G, Muwanika, V B, Heller, R, Balinda, S N, Masembe, C & Siegismund, H R 2010, ' Evolutionary analysis of foot-and-mouth disease virus serotype SAT 1 isolates from east africa suggests two independent introductions from southern africa ', B M C Evolutionary Biology, vol. 10, no. 371 . https://doi.org/10.1186/1471-2148-10-371, Sangula, A K, Belsham, G, Muwanika, V B, Heller, R, Balinda, S N, Masembe, C & Siegismund, H R 2010, ' Evolutionary analysis of foot-and-mouth disease virus serotype SAT 1 isolates from East Africa suggests two independent introductions from southern Africa ', BMC Evolutionary Biology, vol. 10, no. 1, pp. 371 . https://doi.org/10.1186/1471-2148-10-371, BMC Evolutionary Biology
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- Background In East Africa, foot-and-mouth disease virus serotype SAT 1 is responsible for occasional severe outbreaks in livestock and is known to be maintained within the buffalo populations. Little is known about the evolutionary forces underlying its epidemiology in the region. To enhance our appreciation of the epidemiological status of serotype SAT 1 virus in the region, we inferred its evolutionary and phylogeographic history by means of genealogy-based coalescent methods using 53 VP1 coding sequences covering a sampling period from 1948-2007. Results The VP1 coding sequence of 11 serotype SAT 1 FMD viruses from East Africa has been determined and compared with known sequences derived from other SAT 1 viruses from sub-Saharan Africa. Purifying (negative) selection and low substitution rates characterized the SAT 1 virus isolates in East Africa. Two virus groups with probable independent introductions from southern Africa were identified from a maximum clade credibility tree. One group was exclusive to Uganda while the other was present within Kenya and Tanzania. Conclusions Our results provide a baseline characterization of the inter-regional spread of SAT 1 in sub-Saharan Africa and highlight the importance of a regional approach to trans-boundary animal disease control in order to monitor circulating strains and apply appropriate vaccines.
- Subjects :
- Serotype
Evolution
Zoology
Biology
Africa, Southern
Virus
Coalescent theory
Evolution, Molecular
SDG 3 - Good Health and Well-being
parasitic diseases
QH359-425
medicine
Selection, Genetic
Clade
Ecology, Evolution, Behavior and Systematics
Foot-and-mouth disease
Sequence Analysis, RNA
Outbreak
Bayes Theorem
Africa, Eastern
medicine.disease
biology.organism_classification
Phylogeography
Foot-and-Mouth Disease Virus
RNA, Viral
Capsid Proteins
Foot-and-mouth disease virus
Research Article
Subjects
Details
- ISSN :
- 14712148
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- BMC Evolutionary Biology
- Accession number :
- edsair.doi.dedup.....88f08829dbf03aa5fe26963f212aba1a