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Control of Synaptic Strength by Glial TNFα
- Source :
- Science. 295:2282-2285
- Publication Year :
- 2002
- Publisher :
- American Association for the Advancement of Science (AAAS), 2002.
-
Abstract
- Activity-dependent modulation of synaptic efficacy in the brain contributes to neural circuit development and experience-dependent plasticity. Although glia are affected by activity and ensheathe synapses, their influence on synaptic strength has largely been ignored. Here, we show that a protein produced by glia, tumor necrosis factor alpha (TNFalpha), enhances synaptic efficacy by increasing surface expression of AMPA receptors. Preventing the actions of endogenous TNFalpha has the opposite effects. Thus, the continual presence of TNFalpha is required for preservation of synaptic strength at excitatory synapses. Through its effects on AMPA receptor trafficking, TNFalpha may play roles in synaptic plasticity and modulating responses to neural injury.
- Subjects :
- medicine.medical_specialty
AMPA receptor
Biology
Hippocampus
Synaptic Transmission
Receptors, Tumor Necrosis Factor
Rats, Sprague-Dawley
Antigens, CD
Internal medicine
Synaptic augmentation
Metaplasticity
medicine
Animals
Receptors, AMPA
Cells, Cultured
Neurons
Neuronal Plasticity
Multidisciplinary
Synaptic scaling
Tumor Necrosis Factor-alpha
Synaptic pharmacology
Glutamate receptor
Rats
Synaptic fatigue
Endocrinology
Gene Expression Regulation
Receptors, Tumor Necrosis Factor, Type I
Astrocytes
Culture Media, Conditioned
Synapses
Synaptic plasticity
Neuroscience
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 295
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....88e6930cd25d5583a53aafc9a393de70
- Full Text :
- https://doi.org/10.1126/science.1067859