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Role of miRNAs in treatment response and toxicity of childhood acute lymphoblastic leukemia
- Source :
- Pharmacogenomics. 19(4)
- Publication Year :
- 2018
-
Abstract
- Childhood acute lymphoblastic leukemia survival rates have increased remarkably during last decades due, in part, to intensive treatment protocols. However, therapy resistance and toxicity are still two important barriers to survival. In this context, pharmacoepigenetics arises as a tool to identify new predictive markers, required to guide clinicians on risk stratification and dose individualization. The present study reviews current evidence about miRNA implication on childhood acute lymphoblastic leukemia therapy resistance and toxicity. A total of 12 studies analyzing differential miRNA expression in relation to drug resistance and six studies exploring the association between miRNAs-related SNPs and drug-induced toxicities were identified. We pointed out to miR-125b together with miR-99a and/or miR-100 overexpression as markers of vincristine resistance and rs2114358 in mir-1206 as mucositis marker as the most promising results.
- Subjects :
- 0301 basic medicine
Oncology
Vincristine
medicine.medical_specialty
Context (language use)
Antineoplastic Agents
Drug resistance
Polymorphism, Single Nucleotide
03 medical and health sciences
0302 clinical medicine
Internal medicine
microRNA
Genetics
medicine
Mucositis
SNP
Animals
Humans
Childhood Acute Lymphoblastic Leukemia
Pharmacology
business.industry
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Survival Rate
MicroRNAs
030104 developmental biology
Pharmacogenetics
030220 oncology & carcinogenesis
Toxicity
Molecular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 17448042
- Volume :
- 19
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Pharmacogenomics
- Accession number :
- edsair.doi.dedup.....88e520980fc2dd15c06c0c59a3f3f2d2