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A Comparison of the Neuroprotective Efficacy of Pharmacological Pretreatment and Antidotal Treatment in Soman-Poisoned Rats
- Source :
- Acta Medica, Vol 46, Iss 3, Pp 101-107 (2003)
- Publication Year :
- 2003
- Publisher :
- Karolinum Press, 2003.
-
Abstract
- 1. To study the influence of pharmacological pretreatment (PANPAL or pyridostigmine combined with biperiden) and antidotal treatment (the oxime HI-6 plus atropine) on soman-induced neurotoxicity, male albino rats were poisoned with a lethal dose of soman (54 (g/kg i.m.; 100% of LD50 value) and observed at 24 hours and 7 days following soman challenge. The neurotoxicity of soman was evaluated using a Functional observational battery and an automatic measurement of motor activity. 2. Pharmacological pretreatment as well as antidotal treatment were able to eliminate some of soman-induced neurotoxic effects observed at 24 hours following soman poisoning. The combination of pharmacological pretreatment (PANPAL or pyridostigmine combined with biperiden) and antidotal treatment was found to be more effective in the elimination of soman-induced neurotoxicity in rats at 24 hours following soman challenge in comparison with the administration of pharmacological pretreatment or antidotal treatment alone. To compare both pharmacological pretreatments, the combination of pyridostigmine with biperiden seems to be more efficacious to eliminate soman-induced signs of neurotoxicity than PANPAL. 3. At 7 days following soman poisoning, the combination of pharmacological pretreatment involving pyridostigmine and biperiden with antidotal treatment was only able to completely eliminate somaninduced neurotoxic signs. 4. Thus, our findings confirm that the combination of pharmacological pretreatment and antidotal treatment is able not only to protect the experimental animals from the lethal effects of soman but also to eliminate most soman-induced signs of neurotoxicity in poisoned rats. The pharmacological pretreatment containing pyridostigmine and biperiden appears to be more efficacious to eliminate soman-induced neurotoxic sings than PANPAL.
- Subjects :
- Atropine
Male
Cholinesterase Reactivators
050402 sociology
Premedication
Antidotes
Soman
lcsh:Medicine
Pyridinium Compounds
Pharmacology
Functional observational battery
Neuroprotection
Motor activity
Biperiden
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
0504 sociology
Oximes
medicine
Animals
Chemical Warfare Agents
Rats, Wistar
Pyridostigmine
030203 arthritis & rheumatology
business.industry
05 social sciences
Lethal dose
lcsh:R
Neurotoxicity
General Medicine
medicine.disease
Rats
Trihexyphenidyl
Drug Combinations
Neuroprotective Agents
chemistry
Benactyzine
PANPAL
Drug Therapy, Combination
Cholinesterase Inhibitors
business
medicine.drug
Pyridostigmine Bromide
Subjects
Details
- Language :
- English
- ISSN :
- 18059694 and 12114286
- Volume :
- 46
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Acta Medica
- Accession number :
- edsair.doi.dedup.....88df5a7e4729826580c33065d3ea870e