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Effects of cilostazol against the progression of carotid IMT in symptomatic ischemic stroke patients
- Source :
- Journal of Neurology
- Publication Year :
- 2012
- Publisher :
- Springer-Verlag, 2012.
-
Abstract
- Carotid intima-media thickness (IMT) is a surrogate marker for evaluating atherosclerotic vascular diseases. The phosphodiesterase inhibitor cilostazol attenuates the increase in carotid IMT in diabetes patients. We studied whether cilostazol can reduce the progression of carotid IMT in symptomatic ischemic stroke patients. From our prospective registry of acute ischemic stroke patients who were admitted during a 4.5-year period, follow-up carotid ultrasound was performed in a random sample of survivors. Patients were divided into two groups: the cilostazol group, who continued cilostazol treatment during the follow-up period; and the control group, who were prescribed antiplatelets other than cilostazol. Analysis of covariance and propensity score-matched analysis were used to evaluate the difference between groups. Among a total of 1,049 cases in our registry, 208 patients were utilized to construct two comparable sets by propensity score analysis, including 101 who received cilostazol and 107 who took antiplatelet medication without cilostazol. Both maximum and mean carotid IMT values were significantly reduced in the cilostazol group but increased in the control group (maximum left –0.048 ± 0.186 vs. 0.022 ± 0.163 mm, p = 0.001; maximum right –0.037 ± 0.173 vs. 0.050 ± 0.200 mm, p = 0.001; mean left –0.052 ± 0.102 vs. 0.023 ± 0.112 mm, p
- Subjects :
- Adult
Male
medicine.medical_specialty
Carotid Artery, Common
Clinical Neurology
Myocardial Infarction
Tetrazoles
Phosphodiesterase 3 Inhibitors
Carotid Intima-Media Thickness
Diabetes mellitus
Internal medicine
medicine
Humans
Myocardial infarction
cardiovascular diseases
Prospective Studies
Prospective cohort study
Stroke
Aged
Retrospective Studies
Analysis of Variance
Original Communication
business.industry
Surrogate endpoint
Cholesterol, HDL
Retrospective cohort study
Middle Aged
medicine.disease
Atherosclerosis
Cilostazol
Neurology
Ischemic Attack, Transient
Propensity score matching
Cardiology
cardiovascular system
Disease Progression
Female
Neurology (clinical)
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14321459 and 03405354
- Volume :
- 260
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology
- Accession number :
- edsair.doi.dedup.....88d73067a30c47f2f0ac5c5280097fba