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Dopamine Depletion Impairs Frontostriatal Functional Connectivity during a Set-Shifting Task
- Source :
- The Journal of Neuroscience. 28:3697-3706
- Publication Year :
- 2008
- Publisher :
- Society for Neuroscience, 2008.
-
Abstract
- We investigated the effect of transient dopamine depletion on functional connectivity during performance of the Wisconsin Card Sorting Task. Functional magnetic resonance imaging data were analyzed as a psychophysiological interaction, a statistical method used to identify functional connectivity during experimental manipulations. Nineteen healthy subjects were scanned, double blind, on 2 separate days: once after drinking an amino acid mixture deficient in the dopamine precursors tyrosine and phenylalanine, and once after drinking a nutritionally balanced mixture. In the balanced drink session, statistically significant connectivity between the frontal lobes and striatum was observed during set shifting, and the greater the prefrontostriatal connectivity, the faster the response time after a shift. Neither of these associations were observed after dopamine depletion. Moreover, dopamine depletion also reduced the degree of deactivation in areas normally suppressed during attention-demanding tasks, including the medial prefrontal cortex, posterior cingulate cortex, and hippocampus. Together, these results suggest that functional connectivity between the frontal lobes and basal ganglia during set shifting contributes to more efficient performance and that dopamine modulates this corticostriatal connectivity.
- Subjects :
- Adult
Male
Dopamine
Hippocampus
Neuropsychological Tests
Double-Blind Method
Neural Pathways
Basal ganglia
Image Processing, Computer-Assisted
Psychophysics
Reaction Time
medicine
Humans
Attention
Amino Acids
Prefrontal cortex
Food, Formulated
Brain Mapping
medicine.diagnostic_test
General Neuroscience
Cognitive flexibility
Psychophysiological Interaction
Articles
Magnetic Resonance Imaging
Corpus Striatum
Frontal Lobe
Oxygen
Posterior cingulate
Female
Psychology
Functional magnetic resonance imaging
Neuroscience
medicine.drug
Subjects
Details
- ISSN :
- 15292401 and 02706474
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- The Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....88c22fb7629d78d721a5eb1f1ce6f574