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Recurrent desmoplastic small round cell tumor responding to an mTOR inhibitor containing regimen
- Source :
- Pediatric bloodcancer. 65(1)
- Publication Year :
- 2016
-
Abstract
- Desmoplastic small round cell tumor (DSRCT) is a rare mesenchymal tumor that typically presents with multiple abdominal masses. Initial treatment is multimodal in nature. Patients with relapsed DSRCT have a poor prognosis, and there are no standard therapies. We report our experience with five patients treated with vinorelbine, cyclophosphamide, and temsirolimus (VCT). Median number of VCT courses delivered was 7 (range 4–14 courses), and partial response was observed in all patients. Median time to progression or relapse was 8.5 months (range 7–16 months). Neutropenia and mucositis were most common toxicities (n = 4 each).
- Subjects :
- 0301 basic medicine
Oncology
Adult
Male
Mucositis
medicine.medical_specialty
Neutropenia
Cyclophosphamide
Desmoplastic small-round-cell tumor
Adolescent
Desmoplastic Small Round Cell Tumor
Vinorelbine
Vinblastine
03 medical and health sciences
0302 clinical medicine
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Child
Sirolimus
business.industry
Hematology
medicine.disease
Temsirolimus
Surgery
Regimen
030104 developmental biology
030220 oncology & carcinogenesis
Pediatrics, Perinatology and Child Health
Female
Sarcoma
Neoplasm Recurrence, Local
business
medicine.drug
Subjects
Details
- ISSN :
- 15455017
- Volume :
- 65
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Pediatric bloodcancer
- Accession number :
- edsair.doi.dedup.....88b1a75d6b496c4ec0362956a3db542f