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Associations Between Antibody Fc-Mediated Effector Functions and Long-Term Sequelae in Ebola Virus Survivors
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 12 (2021)
- Publication Year :
- 2021
-
Abstract
- Antibodies that mediate non-neutralizing functions play an important role in the immune response to Ebola virus (EBOV) and are thought to impact disease outcome. EBOV has also been associated with long term sequelae in survivors, however, the extent to which antibodies that mediate non-neutralizing functions are associated with the development of these sequelae is unknown. Here, the presence of antibodies mediating different effector functions and how they relate to long-term sequelae two years after the 2007 Bundibugyo Ebola virus (BDBV) outbreak was investigated. The majority of survivors demonstrated robust antibody effector functional activity and demonstrated persistent polyfunctional antibody profiles to the EBOV glycoprotein (GP) two years after infection. These functions were strongly associated with the levels of GP-specific IgG1. The odds of developing hearing loss, one of the more common sequelae to BDBV was reduced when antibodies mediating antibody dependent cellular phagocytosis (ADCP), antibody dependent complement deposition (ADCD), or activating NK cells (ADNKA) were observed. In addition, hearing loss was associated with increased levels of several pro-inflammatory cytokines and levels of these pro-inflammatory cytokines were associated with lower ADCP. These results are indicating that a skewed antibody profile and persistent inflammation may contribute to long term outcome in survivors of BDBV infection
- Subjects :
- 0301 basic medicine
Time Factors
Hearing loss
030231 tropical medicine
Immunology
Inflammation
medicine.disease_cause
Antibodies, Viral
Disease Outbreaks
03 medical and health sciences
0302 clinical medicine
Immune system
Phagocytosis
medicine
Immunology and Allergy
Humans
antibodies
Survivors
Antigens, Viral
Original Research
chemistry.chemical_classification
Ebola virus
biology
business.industry
Effector
Outbreak
Complement System Proteins
RC581-607
Hemorrhagic Fever, Ebola
Ebolavirus
Immunoglobulin Fc Fragments
030104 developmental biology
chemistry
Fc-mediated antibody functions
inflammation
Host-Pathogen Interactions
Ebola
long term sequelae
biology.protein
Immunologic diseases. Allergy
medicine.symptom
Antibody
Glycoprotein
business
Biomarkers
Subjects
Details
- ISSN :
- 16643224
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in immunology
- Accession number :
- edsair.doi.dedup.....88af552d0be99946d0b49efcd1a62764