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The angiotensin II antagonist saralasin inhibits ovulation in the perfused rat ovary

Authors :
Teri Butler
Cheng Zhu
J. Frederick Woessner
William J. LeMaire
C. Matthew Peterson
Tetsunori Mukaida
Source :
American Journal of Obstetrics and Gynecology. 168:242-245
Publication Year :
1993
Publisher :
Elsevier BV, 1993.

Abstract

Our null hypothesis was that the angiotensin II antagonist saralasin does not reduce the number of ovulations in the rat ovarian perfusion model.Ovaries from pregnant mare's serum gonadotropin-stimulated immature rats were perfused with nutrient media to which luteinizing hormone and 3-isobutyl-1-methylxanthine had been added to induce ovulation. Test perfusions were treated with saralasin 1 mumol/L (n = 0.5) and compared with controls (n = 5) with the Student t test. Perfusions with both saralasin and angiotensin II and dose-response evaluations were performed.Saralasin-treated ovulations were 6.6 +/- 1.3 (mean + SEM) compared with 18.6 +/- 3.9, p0.02. The effects of saralasin could be reversed with the addition of an equimolar amount of angiotensin II. Dose-response evaluations showed a progressive inhibition of ovulation at 10(-8) to 10(-6) mol/L.The angiotensin II antagonist saralasin inhibits ovulation in a dose-dependent fashion; this effect is canceled by the addition of equimolar concentrations of angiotensin II.

Details

ISSN :
00029378
Volume :
168
Database :
OpenAIRE
Journal :
American Journal of Obstetrics and Gynecology
Accession number :
edsair.doi.dedup.....88ad38a80a64c96fa1c07b9fe87b5b3f
Full Text :
https://doi.org/10.1016/s0002-9378(12)90920-5