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The angiotensin II antagonist saralasin inhibits ovulation in the perfused rat ovary
- Source :
- American Journal of Obstetrics and Gynecology. 168:242-245
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- Our null hypothesis was that the angiotensin II antagonist saralasin does not reduce the number of ovulations in the rat ovarian perfusion model.Ovaries from pregnant mare's serum gonadotropin-stimulated immature rats were perfused with nutrient media to which luteinizing hormone and 3-isobutyl-1-methylxanthine had been added to induce ovulation. Test perfusions were treated with saralasin 1 mumol/L (n = 0.5) and compared with controls (n = 5) with the Student t test. Perfusions with both saralasin and angiotensin II and dose-response evaluations were performed.Saralasin-treated ovulations were 6.6 +/- 1.3 (mean + SEM) compared with 18.6 +/- 3.9, p0.02. The effects of saralasin could be reversed with the addition of an equimolar amount of angiotensin II. Dose-response evaluations showed a progressive inhibition of ovulation at 10(-8) to 10(-6) mol/L.The angiotensin II antagonist saralasin inhibits ovulation in a dose-dependent fashion; this effect is canceled by the addition of equimolar concentrations of angiotensin II.
- Subjects :
- Ovulation
medicine.medical_specialty
Gonadotropins, Equine
media_common.quotation_subject
Ovary
Rats, Sprague-Dawley
chemistry.chemical_compound
Internal medicine
medicine
Animals
media_common
Dose-Response Relationship, Drug
business.industry
Angiotensin II
Antagonist
Obstetrics and Gynecology
In vitro
Rats
Perfusion
Endocrinology
medicine.anatomical_structure
chemistry
Female
Saralasin
business
Luteinizing hormone
Subjects
Details
- ISSN :
- 00029378
- Volume :
- 168
- Database :
- OpenAIRE
- Journal :
- American Journal of Obstetrics and Gynecology
- Accession number :
- edsair.doi.dedup.....88ad38a80a64c96fa1c07b9fe87b5b3f
- Full Text :
- https://doi.org/10.1016/s0002-9378(12)90920-5