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Autoantibody and metalloproteinase activity in early arthritis
- Source :
- Clinical Rheumatology. 38:827-834
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- The aim of the study was to evaluate the frequency of anti-mutated citrullinated vimentin antibodies (a-Sa), anti-citrullinated α-enolase peptide 1 antibodies (a-CEP-1), anti-filaggrin antibodies (AFAs), heterogeneous nuclear ribonucleoprotein compies/anti-RA33-antibodies (a-hnRNP/RA33), anti-carbamylated protein antibodies (a-CarP), and metalloproteinase (MMPs) activity in patients with early inflammatory arthritis (EIA). Seventy-four patients with EIA: 51 diagnosed with RA (rheumatoid arthritis) and 23 with UA (undifferentiated arthritis), and 20 healthy volunteers were enrolled to the study. Inflammatory markers, rheumatoid factor (RF), and antibodies mentioned above were assessed in all patients. In the EIA group, we observed significantly higher concentration of a-CEP-1 (65.8 ± 111.6 RU/mL) than in controls (2.0 ± 0.0 RU/mL). In RF(+) RA patients, we observed higher concentration of a-Sa and a-CEP-1 than in other groups. A-Sa were positive in 69% of RF(+) RA, 37% of RF(−) RA, 26% of UA patients and in 10% of controls. A–CEP-1 were positive in 77% of RF(+) RA patients, in 56% of RF(−) RA patients, in 8.7% of UA patients, but they were negative in controls. In patients with RF(+) RA, positive a-CarP were present statistically significantly more often than in RF (−) RA patients. No statistically significant difference in frequency of a-hnRNP/RA33 and AFA between RF(+) RA, RF(−) RA, and UA was observed. Our results suggest that a-CEP-1 may help in differentiation between RF(−) RA and UA. a-CEP-1 and a-Sa may be useful while diagnosing EIA. a-CarP may be used in differentiation of RA RF(−) and UA. However, a follow-up study is needed to evaluate the prognostic value of analyzed antibodies.
- Subjects :
- Adult
Male
medicine.medical_specialty
Heterogeneous nuclear ribonucleoprotein
Filaggrin Proteins
Gastroenterology
Anti-Citrullinated Protein Antibodies
Heterogeneous-Nuclear Ribonucleoproteins
Arthritis, Rheumatoid
03 medical and health sciences
0302 clinical medicine
Intermediate Filament Proteins
Rheumatology
Rheumatoid Factor
Internal medicine
Matrix Metalloproteinases, Secreted
Biomarkers, Tumor
Humans
Rheumatoid factor
Medicine
030212 general & internal medicine
Aged
Autoantibodies
030203 arthritis & rheumatology
Protein Carbamylation
biology
business.industry
Arthritis
Tumor Suppressor Proteins
Autoantibody
General Medicine
Early Inflammatory Arthritis
Middle Aged
medicine.disease
DNA-Binding Proteins
Matrix Metalloproteinase 9
Case-Control Studies
Phosphopyruvate Hydratase
Rheumatoid arthritis
biology.protein
Female
Matrix Metalloproteinase 3
RA33
Antibody
business
Subjects
Details
- ISSN :
- 14349949 and 07703198
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Clinical Rheumatology
- Accession number :
- edsair.doi.dedup.....88ac15b091eab32411885da0c879ddb1