Back to Search
Start Over
Immune response profiling in patients with traumatic injuries associated with alcohol ingestion
- Source :
- Clinical and Translational Science, Vol 14, Iss 5, Pp 1791-1798 (2021), Clinical and Translational Science
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Traumatic injuries afflict more than 5 million people globally every year. Current and past animal research has demonstrated association among alcohol, trauma, and impaired immune function, whereas human registries have shown association between alcohol and morbidity as well as mortality. The purpose of this study is to elucidate the immune interactions with alcohol in traumatically injured patients. We prospectively enrolled 379 patients after trauma at three medical centers in the Surgical Critical Care Initiative. Plasma was analyzed using Luminex for up to 35 different cytokines. Collected samples were grouped by patients with detectable plasma alcohol levels versus those without. Univariate testing determined differences in analytes between groups. We built Bayesian belief networks with multiple minimum descriptive lengths to compare the two groups. All 379 patient samples were analyzed. Two hundred eighty‐two (74.4%) patients were men, and 143 (37.7%) were White. Patients had a median intensive care unit length of stay (LOS) of 5.8 days and hospital LOS of 12 days. Using single variate analyses, eight different cytokines were differentially associated with alcohol. Cytokines IL‐12 and IL‐6 were important nodes in both models and IL‐10 was a prominent node in the nonalcohol model. This study found select immune function differed between traumatically injured patients with measurable serum alcohol levels as compared with those without. Traumatically injured patients with positive blood alcohol content appear less able to inhibit inflammatory stress. Alcohol appears to suppress pro‐inflammatory IL‐12 and IL‐6, whereas patients without alcohol have greater levels of anti‐inflammatory IL‐10 expressed at injury and may better regulate anti‐inflammatory pathways. Future studies should determine the relationship with these markers with clinically oriented outcomes.
- Subjects :
- Adult
Male
medicine.medical_specialty
Future studies
Inflammatory stress
Alcohol Drinking
Alcohol
RM1-950
General Biochemistry, Genetics and Molecular Biology
Article
law.invention
chemistry.chemical_compound
Immune system
law
Internal medicine
Medicine
Humans
In patient
Prospective Studies
General Pharmacology, Toxicology and Pharmaceutics
ALCOHOL INGESTION
Ethanol
business.industry
Interleukin-6
General Neuroscience
Research
Bayes Theorem
General Medicine
Articles
Length of Stay
Middle Aged
Intensive care unit
Interleukin-12
Interleukin-10
chemistry
Wounds and Injuries
Blood alcohol content
Female
Therapeutics. Pharmacology
Public aspects of medicine
RA1-1270
business
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 17528054 and 17528062
- Volume :
- 14
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Clinical and Translational Science
- Accession number :
- edsair.doi.dedup.....88a8964b1265f027c33cfe4f328e256a