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Esophageal Cancer: An Updated Review
- Source :
- Southern medical journal. 114(3)
- Publication Year :
- 2021
-
Abstract
- The incidence of esophageal cancer (EC) is on the rise. With the distinct subtypes of adenocarcinoma and squamous cell carcinoma comes specific risk factors, and as a result, people of certain regions of the world can be more prone to a subtype. For example, squamous cell carcinoma of the esophagus has the highest incidence in eastern Africa and eastern Asia, with smoking being a major risk factor, whereas adenocarcinoma is more prevalent in North America and western Europe, with gastroesophageal reflux disease being a leading risk factor. With that being said, adenocarcinoma and squamous cell carcinoma have similar and unfortunately poor survival rates, partly because EC is prone to early metastasis given that the esophagus does not have a serosa, as well as the superficial nature of its lymphatics compared with the rest of the gastrointestinal tract. This makes early detection of the utmost importance, and certain patients have been shown to have the benefit of screening/surveillance endoscopies, including those with Barrett's esophagus, lye-induced/caustic strictures, tylosis, and Peutz-Jeghers syndrome. Until treatments significantly improve, identifying EC at the earliest stage will have the best success for patient outcomes, and further elucidation of its pathogenesis and risk factors may lead to identifying other high-risk groups that should be screened.
- Subjects :
- medicine.medical_specialty
Esophageal Neoplasms
Adenocarcinoma
Global Health
Gastroenterology
Metastasis
Risk Factors
Internal medicine
medicine
Carcinoma
Humans
Risk factor
Esophagus
Survival rate
Early Detection of Cancer
business.industry
Incidence (epidemiology)
Incidence
Smoking
General Medicine
Esophageal cancer
medicine.disease
digestive system diseases
Survival Rate
medicine.anatomical_structure
Carcinoma, Squamous Cell
Gastroesophageal Reflux
business
Subjects
Details
- ISSN :
- 15418243
- Volume :
- 114
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Southern medical journal
- Accession number :
- edsair.doi.dedup.....88a7c44793633cb1eee166ad77d4c10b