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Rapid Evolution of the MH Class I Locus Results in Different Allelic Compositions in Recently Diverged Populations of Atlantic Salmon
- Source :
- ResearcherID, Molecular Biology and Evolution 22 (2005) 4, Molecular Biology and Evolution, 22(4), 1095-1106
- Publication Year :
- 2005
-
Abstract
- We compared major histocompatibility class I allelic diversity in two currently reproductively isolated Atlantic salmon (Salmo salar) populations (Irish and Norwegian) with a common postglacial origin in order to test for among-population differences in allelic composition and patterns of recombination and point mutation. We also examined the evidence for adaptive molecular divergence at this locus by analyzing the rate of amino acid replacement in relation to a neutral expectation. Contrary to our prediction, and in contrast to the situation for other genetic markers, the two populations have almost nonoverlapping sets of major histocompatibility class I alleles. Although there is a strong signal of point mutation that predates population divergence, recent recombination, acting in similar, but not identical, ways in both populations appears to be a significant force in creating new alleles. Moreover, selection acting on peptide-binding residues seems to favor new recombinant alleles and is likely to be responsible for the rapid divergence between populations. © Society for Molecular Biology and Evolution
- Subjects :
- DNA, Complementary
Population
Locus (genetics)
Celbiologie en Immunologie
Biology
Animal Breeding and Genomics
Major histocompatibility complex
Salmon
Genetics
salar l
Animals
Fokkerij en Genomica
Gene conversion
Allele
Salmo
mate choice
education
Molecular Biology
amino-acid sites
Ecology, Evolution, Behavior and Systematics
Alleles
likelihood method
DNA Primers
Recombination, Genetic
education.field_of_study
Base Sequence
gene conversion
hla-b alleles
detecting positive selection
Reproductive isolation
biology.organism_classification
t-cell-receptor
major histocompatibility complex
Genetic divergence
Genetics, Population
Cell Biology and Immunology
Evolutionary biology
biology.protein
WIAS
farm salmon
Subjects
Details
- ISSN :
- 07374038
- Database :
- OpenAIRE
- Journal :
- ResearcherID, Molecular Biology and Evolution 22 (2005) 4, Molecular Biology and Evolution, 22(4), 1095-1106
- Accession number :
- edsair.doi.dedup.....88a6ee7ab42575ab46bbcac3f9e8072f