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Osteomyelitis caused by Aspergillus species: a review of 310 reported cases
- Source :
- Clinical Microbiology and Infection. 20:559-565
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Aspergillus osteomyelitis is a rare infection. We reviewed 310 individual cases reported in the literature from 1936 to 2013. The median age of patients was 43 years (range, 0–86 years), and 59% were males. Comorbidities associated with this infection included chronic granulomatous disease (19%), haematological malignancies (11%), transplantation (11%), diabetes (6%), pulmonary disease (4%), steroid therapy (4%), and human immunodeficiency virus infection (4%). Sites of infection included the spine (49%), base of the skull, paranasal sinuses and jaw (18%), ribs (9%), long bones (9%), sternum (5%), and chest wall (4%). The most common infecting species were Aspergillus fumigatus (55%), Aspergillus flavus (12%), and Aspergillus nidulans (7%). Sixty-two percent of the individual cases were treated with a combination of an antifungal regimen and surgery. Amphotericin B was the antifungal drug most commonly used, followed by itraconazole and voriconazole. Several combination or sequential therapies were also used experimentally. The overall crude mortality rate was 25%.
- Subjects :
- Microbiology (medical)
medicine.medical_specialty
Antifungal Agents
Itraconazole
Antifungal drug
Comorbidity
Aspergillosis
Gastroenterology
Aspergillus fumigatus
Amphotericin B
Internal medicine
medicine
Humans
aspergillosis
Demography
Voriconazole
Antifungals
biology
Osteomyelitis
osteomyelitis
General Medicine
medicine.disease
biology.organism_classification
Combined Modality Therapy
Survival Analysis
Surgery
Transplantation
Aspergillus
Infectious Diseases
Debridement
immunosuppressed patients
spondylodiscitis
medicine.drug
Subjects
Details
- ISSN :
- 1198743X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Clinical Microbiology and Infection
- Accession number :
- edsair.doi.dedup.....88a3440780c8e80c563ac9badf98da58