Back to Search
Start Over
Vitamin C Mitigates Oxidative Stress and Behavioral Impairments Induced by Deltamethrin and Lead Toxicity in Zebrafish
- Source :
- International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12714, International Journal of Molecular Sciences, Vol 22, Iss 12714, p 12714 (2021), International Journal of Molecular Sciences
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Environmental contamination from toxic metals and pesticides is an issue of great concern due to their harmful effects to human health and the ecosystems. In this framework, we assessed the adverse effects when aquatic organisms are exposed to toxicants such as deltamethrin (DM) and lead (Pb), alone or in combination, using zebrafish as a model. Moreover, we likewise evaluated the possible protective effect of vitamin C (VC) supplementation against the combined acute toxic effects of the two toxicants. Juvenile zebrafish were exposed to DM (2 μg L−1) and Pb (60 μg L−1) alone and in combination with VC (100 μg L−1) and responses were assessed by quantifying acetylcholinesterase (AChE) activity, lipid peroxidation (MDA), some antioxidant enzyme activities (SOD and GPx), three-dimension locomotion responses and changes of elements concentrations in the zebrafish body. Our results show that VC has mitigative effects against behavioral and biochemical alterations induced by a mixture of contaminants, demonstrating that it can be used as an effective antioxidant. Moreover, the observations in the study demonstrate zebrafish as a promising in vivo model for assessing the neuroprotective actions of bioactive compounds.
- Subjects :
- Insecticides
Antioxidant
QH301-705.5
medicine.medical_treatment
vitamin C
Ascorbic Acid
Pharmacology
medicine.disease_cause
Neuroprotection
deltamethrin
lead
protective role
zebrafish
3D locomotion analysis
3D locomotion analysis, Deltamethrin, Lead
Protective role, Vitamin C, Zebrafish
Article
Antioxidants
Catalysis
Inorganic Chemistry
Lipid peroxidation
chemistry.chemical_compound
Nitriles
Pyrethrins
medicine
Animals
Physical and Theoretical Chemistry
Biology (General)
Molecular Biology
Zebrafish
QD1-999
Spectroscopy
Behavior, Animal
Vitamin C
biology
Organic Chemistry
General Medicine
biology.organism_classification
Acetylcholinesterase
Computer Science Applications
Oxidative Stress
Chemistry
chemistry
Toxicity
Water Pollutants, Chemical
Oxidative stress
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12714
- Accession number :
- edsair.doi.dedup.....88a32a0b949165fc151b4961bc6e8fb1
- Full Text :
- https://doi.org/10.3390/ijms222312714